Reduced Functional Connectivity during Working Memory in Turner Syndrome
Reduced Functional Connectivity during Working Memory in Turner Syndrome
复制标题
DOI：
10.1093/cercor/bhr017
复制
发表时间：
2011-11-01
期刊：
影响因子：
3.7
通讯作者：
Reiss, Allan L.
中科院分区：
文献类型：
--
作者：
Bray, Signe;Dunkin, Bria;Reiss, Allan L.
特纳综合征(TS)是一种影响女性的遗传性疾病，由X染色体完全或部分缺失引起。TS的认知特征在语言领域表现出相对的优势，在程序领域表现出相对的劣势，包括工作记忆。神经成像研究发现，顶叶的形态、连接额区和顶区的白质通路以及额背区和顶区的异常激活存在差异。综上所述，这些发现表明额叶和顶叶区域之间的异常功能连接可能与TS的工作记忆损害有关，这是我们在本研究中检验的一个假说。我们对TS和典型的发育受试者进行了扫描，这些受试者在执行视觉空间和语音工作记忆任务时进行了功能磁共振成像。我们根据TS的结构差异在顶叶皮质产生了一个种子区，发现在TS的工作记忆过程中，与背侧额叶区域的功能连接减少。最后，我们发现在TS中，连接性与任务绩效相关。这些发现表明，TS患者的大脑结构异常不仅影响区域活动，还影响区域之间的功能相互作用，这对行为具有重要影响。
Turner syndrome (TS) is a genetic disorder affecting females, resulting from the complete or partial absence of an X chromosome. The cognitive profile of TS shows relative strengths in the verbal domain and weaknesses in the procedural domain, including working memory. Neuroimaging studies have identified differences in the morphology of the parietal lobes, and white matter pathways linking frontal and parietal regions, as well as abnormal activation in dorsal frontal and parietal regions. Taken together these findings suggest that abnormal functional connectivity between frontal and parietal regions may be related to working memory impairments in TS, a hypothesis we tested in the present study. We scanned TS and typically developing participants with functional magnetic resonance imaging while they performed visuospatial and phonological working memory tasks. We generated a seed region in parietal cortex based on structural differences in TS and found that functional connectivity with dorsal frontal regions was reduced during working memory in TS. Finally, we found that connectivity was correlated with task performance in TS. These findings suggest that structural brain abnormalities in TS affect not only regional activity but also the functional interactions between regions and that this has important consequences for behavior.