Glass coating for PDMS microfluidic channels by sol-gel methods
Glass coating for PDMS microfluidic channels by sol-gel methods
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DOI：
10.1039/b800001h
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发表时间：
2008-01-01
期刊：
影响因子：
6.1
通讯作者：
Weitz, David A.
中科院分区：
文献类型：
--
作者：
Abate, Adam R.;Lee, Daeyeon;Weitz, David A.
使用聚二甲基硅氧烷（PDMS）的软光刻技术可以很容易地以低成本制造复杂的微流体装置。然而，PDMS在许多有机溶剂的存在下膨胀会显著降低器件的性能。我们提出了一种用溶胶-凝胶化学方法在PDMS通道上涂上玻璃状层的方法。这种涂层大大提高了通道的耐化学性；此外，它可以与广泛的化学物质功能化，以精确控制界面性质。这种方法结合了软光刻提供的易于制造与玻璃提供的精确控制和化学坚固性。
Soft lithography using polydimethylsiloxane (PDMS) allows one to fabricate complex microfluidic devices easily and at low cost. However, PDMS swells in the presence of many organic solvents significantly degrading the performance of the device. We present a method to coat PDMS channels with a glass-like layer using sol-gel chemistry. This coating greatly increases chemical resistance of the channels; moreover, it can be functionalized with a wide range of chemicals to precisely control interfacial properties. This method combines the ease of fabrication afforded by soft-lithography with the precision control and chemical robustness afforded by glass.