Characterization of site-specific glycosylation of secreted proteins associated with multi-drug resistance of gastric cancer.
Characterization of site-specific glycosylation of secreted proteins associated with multi-drug resistance of gastric cancer.
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与胃癌多药耐药相关的分泌蛋白位点特异性糖基化的表征
DOI：
10.18632/oncotarget.8287
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发表时间：
2016-05-03
期刊：
影响因子：
--
通讯作者：
Fan D
中科院分区：
文献类型：
--
作者：
Wu J;Qin H;Li T;Cheng K;Dong J;Tian M;Chai N;Guo H;Li J;You X;Dong M;Ye M;Nie Y;Zou H;Fan D
多药耐药（MDR）是胃癌有效化疗的一大障碍。许多分泌性糖蛋白参与了胃癌多药耐药的发生。然而，在胃癌多药耐药过程中，分泌糖蛋白的糖基化是否发生变化尚不清楚。本研究首次发现耐药细胞系分泌蛋白的N-糖基和位点特异性糖型与亲本细胞系明显不同。进一步的研究表明，某些糖基化异常的分泌蛋白在胃癌多药耐药中具有重要意义，提示调控特定糖蛋白的糖基化可能成为克服胃癌多药耐药的潜在靶点。
Multi-drug resistance (MDR) remains a great obstacle to effective chemotherapy for gastric cancer. A number of secreted glycoproteins have been reported to be involved in the development of MDR in gastric cancer. However, whether glycosylation of secreted glycoproteins changes during MDR of gastric cancer is unclear. Our present work manifested that N-glycosites and site-specific glycoforms of secreted proteins in drug-resistant cell lines were distinctly different from those in the parental cell line for the first time. Further characterization highlighted the significance of some aberrantly glycosylated secretory proteins in MDR, suggesting that manipulating the glycosylation of specific glycoproteins could be a potential target for overcoming multi-drug resistance in gastric cancer.
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