Amyloid-β42 is Associated with Cognitive Impairment in Healthy Elderly and Subjective Cognitive Impairment
Amyloid-β42 is Associated with Cognitive Impairment in Healthy Elderly and Subjective Cognitive Impairment
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DOI：
10.3233/jad-2011-110038
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发表时间：
2011-01-01
影响因子：
4
通讯作者：
Wallin, Anders
中科院分区：
文献类型：
--
作者：
Rolstad, Sindre;Berg, Anne Ingeborg;Wallin, Anders
这项研究的目的是根据脑脊液(CSF)生物标记物总tau(T-tau)和淀粉样β蛋白(42)(A beta(42))来预测不同损害程度的对照组和患者的认知表现。以前的研究已经发现脑脊液T-tau水平与认知症状有关，但很难将Aβ与认知联系起来，因此假设Aβ在认知症状之前达到平台期水平。一系列全面的神经心理测试被进行了因素分析，以得出聚合的认知域。对哥德堡MCI研究的总样本(n=435)和每种损伤程度进行了线性回归模型。在总样本中，Aβ(42分)和T-tau在所有认知领域的表现中占了相当大的比例。在对照组(n=60)和有主观认知障碍的患者(n=105)中，Aβ(42)预测了相当大比例的语义和工作记忆表现。对于轻度认知障碍患者(n=170)，T-tau对认知领域的影响最显著，尤其是对情景记忆、视觉空间和速度/执行能力的影响。对于痴呆症患者(n=100)，Aβ(42)对情节记忆和视觉空间功能的影响最显著，而T-tau与情节记忆密切相关。我们的结果表明，认知与脑脊液生物标志物有关，与损伤程度无关。Aβ(42)与从潜在的早期疾病阶段到后期疾病阶段的认知功能有关，而T-tau更能指示疾病后期的表现。
The aim of this study was to predict cognitive performance on the basis of the cerebrospinal fluid (CSF) biomarkers total tau (T-tau) and amyloid-beta(42) (A beta(42)) in controls and patients at various impairment levels. Previous studies have found an association of CSF T-tau levels with cognitive symptoms, but it has been difficult to relate A beta to cognition, and it has thus been hypothesized that A beta reaches a plateau level prior to cognitive symptoms. A comprehensive battery of neuropsychological tests was subjected to factor analysis to yield aggregated cognitive domains. Linear regression models were performed for the total sample of the Gothenburg MCI study (n = 435) and for each level of impairment. A beta(42) and T-tau accounted for a significant proportion of performance in all cognitive domains in the total sample. In controls (n = 60) and patients with subjective cognitive impairment (n = 105), A beta(42) predicted a significant proportion of semantic and working memory performance. For patients with mild cognitive impairment (n = 170), T-tau had the most pronounced impact across cognitive domains, and more specifically on episodic memory, visuospatial, and speed/executive performance. For patients with dementia (n = 100), the most pronounced impacts of A beta(42) were found in episodic memory and visuospatial functioning, while T-tau was substantially associated with episodic memory. Our results suggest that cognition is related to CSF biomarkers regardless of impairment level. A beta(42) is associated with cognitive functions from a potentially early to a later disease phase, and T-tau is more indicative of performance in a later disease phase.