Serum Myeloperoxidase levels independently predict endothelial dysfunction in humans
Serum Myeloperoxidase levels independently predict endothelial dysfunction in humans
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DOI：
10.1161/01.cir.0000140262.20831.8f
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发表时间：
2004-08-31
期刊：
影响因子：
37.8
通讯作者：
Hazen, SL
中科院分区：
文献类型：
--
作者：
Vita, JA;Brennan, ML;Hazen, SL
背景-体外和动物研究表明，髓过氧化物酶催化消耗一氧化氮作为底物，限制了其生物利用度和功能。因此，我们假设循环中的髓过氧化物酶水平可以预测人类内皮细胞功能障碍的风险。方法和结果-在298名参与一项正在进行的内皮功能障碍临床相关性研究的医院人群中，用酶联免疫测定法测定血清髓过氧化物酶，超声测定肱动脉血流介导的扩张和硝酸甘油介导的扩张(年龄，51+/-16岁；61%的男性，51%的心血管疾病患者)。四分位血清髓过氧化物酶水平升高与肱动脉血流介导的扩张呈显著负相关(分别为11.0+/-6.0%、9.4+/-5.3%、8.6+/-5.8%和6.4+/-4.5%)；
Background-In vitro and animal studies demonstrate that myeloperoxidase catalytically consumes nitric oxide as a substrate, limiting its bioavailability and function. We therefore hypothesized that circulating levels of myeloperoxidase would predict risk of endothelial dysfunction in human subjects.Methods and Results-Serum myeloperoxidase was measured by enzyme-linked immunoassay, and brachial artery flow-mediated dilation and nitroglycerin-mediated dilation were determined by ultrasound in a hospital-based population of 298 subjects participating in an ongoing study of the clinical correlates of endothelial dysfunction (age, 51+/-16; 61% men, 51% with cardiovascular disease). A strong inverse relation between brachial artery flow-mediated dilation and increasing quartile of serum myeloperoxidase level was observed (11.0+/-6.0%, 9.4+/-5.3%, 8.6+/-5.8%, and 6.4+/-4.5% for quartiles 1 through 4, respectively; P