Exercise-induced changes in plasma atrial natriuretic peptide and brain natriuretic peptide concentrations in healthy subjects with chronic sleep deprivation
Exercise-induced changes in plasma atrial natriuretic peptide and brain natriuretic peptide concentrations in healthy subjects with chronic sleep deprivation
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DOI：
10.1253/jcj.63.447
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发表时间：
1999-06-01
期刊：
影响因子：
--
通讯作者：
Murayama, M
中科院分区：
文献类型：
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作者：
Tanabe, K;Yamamoto, A;Murayama, M
近年来的研究表明，血浆心钠素（ANP）和脑钠素（BNP）水平与心力衰竭患者的心功能和预后相关。然而，人们对疲劳等常见生理状态下血浆浓度的变化知之甚少。因此，本研究采用慢性睡眠剥夺模型，观察血浆ANP和BNP浓度的生理变化。对10名健康志愿者（平均年龄：22.7岁）进行了自行车运动心肺功能试验。在静息状态和每次运动试验后立即抽取用于测量ANP和BNP的血液样品。运动试验期间采用阻抗法测定心输出量（CO）。研究条件设计如下：（A）正常睡眠一段时间后的一天（对照状态）和（B）睡眠持续1个月前的一天
Recent observations have shown that plasma levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) correlate with cardiac function or prognosis in heart failure patients. However, relatively little is known about changes in their plasma concentration during commonly occurring physiological states such as fatigue. Therefore, this study was designed to examine the physiological changes of plasma ANP and BNP concentrations using a chronic sleep-deprivation model. Bicycle ergometer cardiopulmonary exercise tests were performed in 10 healthy volunteers (mean age: 22.7 years). Blood samples for measuring ANP and BNP were drawn during the resting state and immediately after each exercise test. Cardiac output (CO) was measured during the exercise test by the impedance method. The study conditions were designed as follows: (A) a day following a period of normal sleep (control state) and (B) a day preceded by 1 month during which sleep lasted