COMPACTIN INHIBITS INSECT HMG-COA REDUCTASE AND JUVENILE-HORMONE BIOSYNTHESIS
COMPACTIN INHIBITS INSECT HMG-COA REDUCTASE AND JUVENILE-HORMONE BIOSYNTHESIS
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DOI：
10.1016/0006-291x(82)90939-1
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发表时间：
1982-01-01
影响因子：
3.1
通讯作者：
LAW, JH
中科院分区：
文献类型：
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作者：
MONGER, DJ;LIM, WA;LAW, JH
烟草天蛾 M. sexta 的体匀浆中 3-羟基-3-甲基戊二酰辅酶 A 还原酶的活性被康克素竞争性抑制。对于来自雄性和雌性阿拉塔体的还原酶，康帕素钠盐形式的 KI 均为 0.9 nM。在完整的雌性阿拉塔体内，保幼激素的生物合成也受到.apprx的抑制。 10 nM 康康汀为 50%。注射康帕汀后，在第 3-4 龄蜕皮后的幼虫中观察到角质层变黑，这是保幼激素缺乏的迹象。 Compactin显示出作为昆虫生长和发育抑制剂的潜力。
The activity of 3-hydroxy-3-methylglutaryl CoA reductase in homogenates of the corpora allata of the tobacco hornworm, M. sexta, was competitively inhibited by compactin. The KI for the sodium salt form of compactin was 0.9 nM for the reductase from both male and female corpora allata. In intact female corpora allata juvenile hormone biosynthesis was also inhibited by .apprx. 50% at 10 nM compactin. Following injection with compactin, darkening of the cuticle, an indication of juvenile hormone deficiency, was observed in larvae after ecdysis from 3rd-4th instar. Compactin shows potential as an inhibitor of insect growth and development.