ABC portal: a single-cell database and web server for blood cells.

ABC portal: a single-cell database and web server for blood cells.
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ABC 门户:血细胞的单细胞数据库和网络服务器

DOI:
10.1093/nar/gkac646
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发表时间:
2023-01-06
影响因子:
14.9
通讯作者:
Cheng, Tao
Cheng, Tao
中科院分区:
生物学2区
文献类型:
--
作者:
Gao, Xin;Hong, Fang;Hu, Zhenyu;Zhang, Zilong;Lei, Yang;Li, Xiaoyun;Cheng, Tao

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ABC门户网站(http:abc.sklehabc.com)是一个数据库和门户网站,包含198个单细胞转录组数据集,这些数据集涉及血液/免疫细胞的发育、分化和紊乱。所有数据集都用手动策划和统一的单细胞参考重新注释,特别是对于造血干细胞和祖细胞。ABC门户网站提供基于网络的交互式分析模块,特别是全面的细胞间通讯分析和疾病相关基因签名分析。重要的是,ABC门户允许基于多个元数据的组合进行定制的样本选择,用于下游分析和跨数据集的比较分析。ABC门户还允许用户在模块中选择多种细胞类型进行分析。ABC门户网站为研究人员和临床医生提供了一个单细胞数据探索和再分析的交互式界面,并为研究人员和临床医生提供了定制的分析模块,并将促进对造血和血液/免疫疾病的理解。
ABC portal (http://abc.sklehabc.com) is a database and web portal containing 198 single-cell transcriptomic datasets of development, differentiation and disorder of blood/immune cells. All the datasets were re-annotated with a manually curated and unified single-cell reference, especially for the haematopoietic stem and progenitor cells. ABC portal provides web-based interactive analysis modules, especially a comprehensive cell-cell communication analysis and disease-related gene signature analysis. Importantly, ABC portal allows customized sample selection based on a combination of several metadata for downstream analysis and comparison analysis across datasets. ABC portal also allows users to select multiple cell types for analysis in the modules. Together, ABC portal provides an interactive interface of single-cell data exploration and re-analysis with customized analysis modules for the researchers and clinicians, and will facilitate understanding of haematopoiesis and blood/immune disorders.
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