Multichannel electroencephalographic assessment of auditory evoked response suppression in schizophrenia
Multichannel electroencephalographic assessment of auditory evoked response suppression in schizophrenia
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DOI：
10.1007/s002210100744
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发表时间：
2001-08-01
影响因子：
2
通讯作者：
Blumenfeld, LD
中科院分区：
文献类型：
--
作者：
Clementz, BA;Blumenfeld, LD
在成对刺激范例中，听觉诱发反应（AER）抑制降低（抑制等于S1和S2振幅之间的差异除以S1振幅）可能是精神分裂症遗传易感性的指标。本文报道了20例正常人和20例精神分裂症患者AER抑制的多导脑电图研究。典型的配对刺激范例被用来唤起时间锁定的AER。使用单通道（Cz）和多通道数据（在使用主成分分析（PCA）减少后）在时域中对P50和N100处的AER反应进行评分，并使用多通道信息（也在PCA后）对伽马（20-50 Hz）和低频（1-20 Hz）范围内的信息进行评分。时域分析表明，精神分裂症患者与正常人的反应幅度的第一，但不是第二，刺激P50和N100。频域数据表明，精神分裂症患者与正常人不同的低频反应（LFR）的幅度的第一个，但没有第二个，刺激。两组在伽马波段反应的幅度上没有显著差异。多通道N100和LFR数据的组分离最大，LFR表明，区分精神分裂症与正常受试者的风险比略好。目前的结果表明，从以前的AER抑制研究的两个新的差异：（1）S1振幅在很大程度上决定正常和精神分裂症组之间的差异AER抑制，（2）频域分析时，研究精神分裂症AER可能提供重要的补充信息。
Reduced auditory evoked response (AER) suppression in a paired-stimulus paradigm (where suppression equals the difference between S1 and S2 amplitudes divided by S1 amplitude) may index genetic liability for schizophrenia. The present report is a multiple-channel electroencephalographic (EEG) study of AER suppression among 20 normal and 20 schizophrenia subjects. The typical paired-stimulus paradigm was used to evoke time-locked AERs. AER responses were scored at P50 and N100 in the time domain using both single (Cz) and multichannel data (after reduction using principal components analysis, PCA), and were scored for information in the gamma (20-50 Hz) and low-frequency (1-20 Hz) ranges using multichannel information (also after PCA). The time domain analyses demonstrated that schizophrenia patients differ from normal in amplitude of response to the first, but not to the second, stimulus for both P50 and N100. The frequency domain data demonstrated that schizophrenia patients differed from normal on amplitude of the low-frequency response (LFR) to the first, but not to the second, stimulus. The groups did not differ significantly on amplitudes of the gamma-band responses. Group separations were largest for the multichannel N100 and LFR data, with the LFR demonstrating, a modestly better risk ratio for differentiating schizophrenia from normal subjects. The present results suggest two novel differences from previous AER suppression studies: (1) S1 amplitudes largely determine differences between normal and schizophrenia groups on AER suppression, and (2) frequency domain analyses may provide important complimentary information when studying AERs in schizophrenia.