Investigation of clinicopathological features of vulvar cancer in 1068 patients: A Japanese Gynecologic Oncology Group (JGOG) nationwide survey study.
Investigation of clinicopathological features of vulvar cancer in 1068 patients: A Japanese Gynecologic Oncology Group (JGOG) nationwide survey study.
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1068 例患者外阴癌临床病理特征的调查：日本妇科肿瘤组 (JGOG) 全国调查研究。
DOI：
10.1016/j.ygyno.2020.08.019
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发表时间：
2020
期刊：
影响因子：
4.7
通讯作者：
Enomoto T.
中科院分区：
文献类型：
--
作者：
Nishio S;Murotani K;Nakao S;Takenaka M;Suzuki S;Aoki Y;Todo Y;Hosaka M;Nakai H;Katabuchi H;Nishi H;Takekuma M;Mikami M;Enomoto T.
目的外阴癌是老年人群中罕见的恶性肿瘤，优化治疗策略需要对该疾病的临床病理特征进行大规模调查。在日本，过去30年没有进行过这样的调查。这项大规模的回顾性多中心研究的目的是研究外阴癌的临床病理特征在Japanes.MethodsUpon获得伦理批准的参与机构的审查委员会，外阴癌患者的医疗记录，谁是治疗2001年和2010年之间进行了审查。使用多变量考克斯回归model.ResultsAfter应用的纳入和排除标准，1068例患者治疗的总生存期（OS）的临床病理因素的影响进行了研究，在108个中心。中位年龄为72岁。402例患者（37.6%）处于I期，249例患者（23.3%）处于II期，252例患者（23.6%）处于III期，165例患者（15.4%）处于IV期。鳞状细胞癌、佩吉特病、腺癌和其他疾病分别在773例（72.4%）、154例（14.4%）、59例（5.5%）和82例（7.7%）患者中得到诊断。腹股沟-股淋巴结阳性265例（24.8%）。I，II，III，IV期外阴癌的5年OS率分别为85.6%，75.1%，48.8%，和40.0%，corresponding.ConclusionOur研究表明，先进的年龄，疾病分期，组织学诊断，肿瘤直径，淋巴结转移显着影响在日本外阴癌患者的OS。
ObjectiveVulvar cancer is a rare malignancy in the aging population, and optimizing treatment strategies requires large-scale investigation of the clinicopathological features of this disease. In Japan, no such surveys have been conducted in the past 30 years. This large-scale retrospective multi-center study aimed to examine the clinicopathological features of vulvar cancer in Japan.MethodsUpon obtaining ethical approval by the participating institutions' review boards, the medical records of patients with vulvar cancer, who were treated between 2001 and 2010 were reviewed. The impact of clinicopathological factors on overall survival (OS) was investigated using a multivariate Cox regression model.ResultsAfter applying the inclusion and exclusion criteria, 1068 patients treated in 108 centers were included. The median age was 72 years. The disease was in stage I in 402 patients (37.6%), stage II in 249 patients (23.3%), stage III in 252 patients (23.6%), and stage IV in 165 patients (15.4%). Squamous cell carcinoma, Paget's disease, adenocarcinoma, and other diseases were diagnosed in 773 (72.4%), 154 (14.4%), 59 (5.5%), and 82 (7.7%) patients, respectively. Positive inguino-femoral lymph nodes were found in 265 (24.8%) patients. The 5-year OS rate for stage I, II, III, and IV vulvar cancer were 85.6%, 75.1%, 48.8%, and 40.0%, respectively.ConclusionOur study shows that advanced age, disease stage, histological diagnosis, tumor diameter, and lymph node metastases significantly affect the OS of patients with vulvar cancer in Japan.