Blockade of NMDA receptors in the anterior forebrain impairs sensory acquisition in the zebra finch (Poephila guttata)
Blockade of NMDA receptors in the anterior forebrain impairs sensory acquisition in the zebra finch (Poephila guttata)
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DOI：
10.1006/nlme.1996.0071
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发表时间：
1996-11-01
影响因子：
2.7
通讯作者：
Nordeen, KW
中科院分区：
文献类型：
--
作者：
Basham, ME;Nordeen, EJ;Nordeen, KW
青少年斑胸草雀（Poephila guttata）学习歌曲分为两个阶段：在感官习得期间，它们记住成年导师的歌曲，在感觉运动学习期间，它们改变自己的发声以匹配存储的歌曲模型。与许多其他形式的神经可塑性和记忆形成一样，斑胸草雀的发声学习受到NMDA受体药理学阻断的损害，但相关的NMDA受体尚未定位。在歌曲发育过程中，一个与歌曲学习特别相关的神经区域IMAN表现出NMDA受体密度增加以及对NMDA拮抗剂MK-801的结合亲和力降低。为了检验感觉获得需要激活IMAN中或附近的NMDA受体的假设，我们将NMDA受体拮抗剂氨基-5-膦酰基戊酸（AP 5; 2.5 μ g/0.1 μ l）直接注入前前脑。在10次辅导之前接受AP 5输注的鸟比假手术的鸟、盐水灌注的鸟、在非辅导日接受AP 5输注的鸟或接受AP 5输注到小脑的鸟复制的导师的歌曲显著更少。此外，在前脑前部注入AP 5不会损害幼鸟区分斑胸草雀和金丝雀的能力。这些发现与前前脑NMDA受体激活是鸟类声乐学习过程中记忆歌曲材料所必需的假设是一致的。这也是第一个报告，歌曲相关的区域的前前脑有助于感觉获得具体。(C)出版社：Academic Press，Inc.
Juvenile zebra finches (Poephila guttata) learn song in two stages: during sensory acquisition, they memorize the song of an adult tutor, and during sensorimotor learning, they alter their vocalizations to match the stored song model. Like many other forms of neural plasticity and memory formation, vocal learning in zebra finches is impaired by pharmacological blockade of NMDA receptors, but the relevant NMDA receptors have not yet been localized. During song development, one neural region that has been implicated specifically in song learning, the IMAN, exhibits an increased density of NMDA receptors as well as decreased binding affinity for the NMDA antagonist MK-801. To test the hypothesis that sensory acquisition requires activation of NMDA receptors in or near the IMAN we infused the NMDA receptor antagonist amino-5-phosphonopentanoic acid (AP5; 2.5 mu g in 0.1 mu l) directly into the anterior forebrain. Birds receiving AP5 infusions prior to each of 10 tutoring sessions copied significantly less of their tutor's song than did sham-operated birds, saline-infused birds, birds that received AP5 infusions on nontutoring days, or birds that received AP5 infusions into the cerebellum. Furthermore, infusions of AP5 in the anterior forebrain did not impair young birds' ability to discriminate zebra finch from canary song. These findings are consistent with the hypothesis that NMDA receptor activation in the anterior forebrain is necessary for the memorization of song material during avian vocal learning. This is also the first report that song-related regions of the anterior forebrain contribute to sensory acquisition specifically. (C) 1996 Academic Press, Inc.