IMMUNOPHILINS IN PROTEIN-FOLDING AND IMMUNOSUPPRESSION
IMMUNOPHILINS IN PROTEIN-FOLDING AND IMMUNOSUPPRESSION
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DOI：
10.1096/fasebj.8.6.7513288
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发表时间：
1994-04-01
期刊：
影响因子：
4.8
通讯作者：
BIERER, BE
中科院分区：
文献类型：
--
作者：
FRUMAN, DA;BURAKOFF, SJ;BIERER, BE
淋巴细胞活化需要将信号从质膜上的分子传递到调节基因表达的核信号。近年来，一些免疫抑制化合物已被用作探针，以确定重要的和潜在的新分子参与淋巴细胞信号转导过程。免疫抑制剂环孢菌素A（CsA），FK 506和雷帕霉素已被特别详细地研究。已经鉴定了两类不同的免疫抑制剂结合蛋白，统称为亲免素。亲免疫素的亲环蛋白家族结合CsA，而FK506结合蛋白（FKBP）家族结合FK506和雷帕霉素。本文就亲免素的内源性功能及其在介导免疫抑制中的作用作一综述。
Lymphocyte activation requires the transmission of signals from molecules at the plasma membrane to nuclear signals that regulate gene expression. In recent years, several immunosuppressive compounds have been used as probes to identify important and potentially novel molecules involved in lymphocyte signal transduction processes. The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin have been studied in particular detail. Two distinct classes of immunosuppressant binding proteins have been identified, and collectively termed immunophilins. The cyclophilin family of immunophilins binds CsA, whereas the FK506-binding protein (FKBP) family binds FK506 and rapamycin. This review will discuss both the endogenous functions of immunophilins as well as their roles in mediating immunosuppression.