APPROACHES TO SUDDEN DEATH FROM CORONARY HEART DISEASE
APPROACHES TO SUDDEN DEATH FROM CORONARY HEART DISEASE
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DOI：
10.1161/01.cir.44.1.130
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发表时间：
1971-01-01
期刊：
影响因子：
37.8
通讯作者：
WOLF, M
中科院分区：
文献类型：
--
作者：
LOWN, B;WOLF, M
心源性猝死（SCD）仍然有增无减。冠心病监护病房虽然可以有效降低医院死亡率，但不能显着减少主要发生在医院外且占冠心病 (CHD) 死亡人数大部分的 SCD。鉴于 SCD 的频繁突发性，只有在事件发生之前识别和保护受害者的计划才有希望成功预防大多数 SCD。由于 SCD 很可能是由心律失常引起，因此药物预防可能有效。鉴于目前可用药物的毒性，在开始药物试验之前必须预先选择风险最高的人群。室性早搏 (VPB) 可识别易患 SCD 的受试者。回顾了 VPB 的流行病学和生理学信息，并提出了旨在确定 VPB 作为 SCD 危险因素的有用性的研究建议。
Sudden cardiac death (SCD) continues unabated. Coronary care units, while effective in lowering hospital mortality, cannot significantly reduce SCD which occurs primarily outside the hospital and accounts for the majority of deaths from coronary heart disease (CHD). In view of the frequent precipitous nature of SCD, only a program which identifies and protects the victim prior to the event can hope to be successful in preventing the majority of SCD. Since it is likely that SCD is due to an arrhythmia, drug prophylaxis might prove effective. In view of the toxicity of currently available agents, it is mandatory to preselect a population at highest risk before embarking on a drug trial. Ventricular premature beats (VPB) may identify subjects susceptible to SCD. Epidemiologic and physiologic information on VPB is reviewed, and proposals are made for studies designed to establish the usefulness of VPB as a risk factor for SCD.