Cholesterol Crystal Embolism and Chronic Kidney Disease.
Cholesterol Crystal Embolism and Chronic Kidney Disease.
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胆固醇结晶栓塞与慢性肾脏病
DOI：
10.3390/ijms18061120
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发表时间：
2017-05-24
影响因子：
5.6
通讯作者：
Zhuang S
中科院分区：
文献类型：
--
作者：
Li X;Bayliss G;Zhuang S
当小片粥样斑块从主动脉或肾动脉脱落并流经下游血管床后，胆固醇晶体滞留在小肾动脉中，就会发生由胆固醇晶体栓塞 (CCE) 引起的肾脏疾病。 CCE 是一种多系统疾病，但肾脏特别容易受到动脉粥样硬化栓塞性疾病的影响，这可能导致肾功能急性、亚急性或慢性下降。这种危及生命的疾病可能会被诊断不足或被忽视，因为它是晚期动脉粥样硬化患者慢性肾脏病 (CKD) 的原因。 CCE 可能由血管手术、血管造影或服用抗凝剂引起。动脉粥样硬化性肾病具有多种临床特征，与其他肾脏疾病和全身性疾病相似。临床上常被误诊，但可通过特征性肾活检结果确诊。治疗选择有限，预后较差。扩大对 CCE 引起的动脉粥样硬化性肾病的认识，为识别、诊断和治疗这种进行性肾功能不全的病因开辟了前景。
Renal disease caused by cholesterol crystal embolism (CCE) occurs when cholesterol crystals become lodged in small renal arteries after small pieces of atheromatous plaques break off from the aorta or renal arteries and shower the downstream vascular bed. CCE is a multisystemic disease but kidneys are particularly vulnerable to atheroembolic disease, which can cause an acute, subacute, or chronic decline in renal function. This life-threatening disease may be underdiagnosed and overlooked as a cause of chronic kidney disease (CKD) among patients with advanced atherosclerosis. CCE can result from vascular surgery, angiography, or administration of anticoagulants. Atheroembolic renal disease has various clinical features that resemble those found in other kidney disorders and systemic diseases. It is commonly misdiagnosed in clinic, but confirmed by characteristic renal biopsy findings. Therapeutic options are limited, and prognosis is considered to be poor. Expanding knowledge of atheroembolic renal disease due to CCE opens perspectives for recognition, diagnosis, and treatment of this cause of progressive renal insufficiency.
影响因子：
0.7
作者：
Nasri H;Mubarak M
通讯作者：
Mubarak M