Rind of the rambutan, Nephelium lappaceum, a potential source of natural antioxidants
Rind of the rambutan, Nephelium lappaceum, a potential source of natural antioxidants
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DOI：
10.1016/j.foodchem.2007.12.018
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发表时间：
2008-07-01
期刊：
影响因子：
8.8
通讯作者：
Radhakrishnan, Ammu K.
中科院分区：
文献类型：
--
作者：
Palanisamy, Uma;Ming, Cheng Hwee;Radhakrishnan, Ammu K.
当使用多种方法进行评估时，发现通常被丢弃的红毛丹果皮含有极高的抗氧化活性。尽管红毛丹皮乙醇提取物的产率仅为 18%，但其总酚含量为 762 +/- 10 mg GAE/g 提取物，与市售的葡萄籽提取物制剂相当。将提取物的促氧化能力与维生素 C、α-生育酚、葡萄籽和绿茶进行比较，果皮的促氧化能力最低。此外。 100 μg/ml 提取物可限制氧化剂诱导的细胞凋亡（DPPH 50 μM），其程度与葡萄籽相似。这些提取物对正常小鼠成纤维细胞或脾细胞没有细胞毒性，而粉状果皮的重金属含量远低于营养保健品的允许水平。我们的研究首次揭示了云母果皮提取物的酚类含量高、促氧化能力低、抗氧化活性强。该提取物无论单独使用还是与其他活性成分结合使用，均可用于化妆品、营养品和制药应用。 (c) 2007 Elsevier Ltd. 保留所有权利。
The rind of rambutan, which is normally discarded was found to contain extremely high antioxidant activity when assessed using several methods. Although having a yield of only 18%, the ethanolic rambutan rind extract had a total phenolic content of 762 +/- 10 mg GAE/g extract, which is comparable to that of a commercial preparation of grape seed extract. Comparing the extract's pro-oxidant capabilities with vitamin C, alpha-tocopherol, grape seed and green tea, the rind had the lowest pro-oxidant capacity. In addition. the extract at 100 mu g/ml was seen to limit oxidant-induced cell death (DPPH at 50 mu M) by apoptosis to an extent similar to that of grape seed. The extracts were not cytotoxic to normal mouse fibroblast cells or splenocytes while the powderised rind was seen to have heavy metals contents far below the permissible levels for nutraceuticals. Our study for the first time reveals the high phenolic content, low pro-oxidant capacity and strong antioxidant activity of the extract from rind of Nephelium lappaceum. This extract, either alone or in combination with other active principles, can be used in cosmetic, nutraceutical and pharmaceutical applications. (c) 2007 Elsevier Ltd. All rights reserved.