Socially mediated alcohol preferences in adolescent rats following interactions with an intoxicated peer
Socially mediated alcohol preferences in adolescent rats following interactions with an intoxicated peer
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DOI：
10.1016/j.pbb.2004.07.010
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发表时间：
2004-10-01
影响因子：
3.6
通讯作者：
Molina, JC
中科院分区：
文献类型：
--
作者：
Fernández-Vidal, JM;Molina, JC
这项研究的重点是“被动的社会影响”（酒精相关的信息获得的生物体，与醉酒的对应），可能会影响酒精偏好的青少年大鼠。进行了五个实验，以调查是否重复的社会互动与醉酒的同行可以产生酒精相关的记忆，导致动物表现出高度酒精嗅觉偏好模式。青少年的经验与酒精操作如下：与酒精中毒的同行（实验1），与酒精香味的棉花替代品（实验2）或与麻醉酒精中毒的合作伙伴（实验35）的相互作用。然后，在双向位置嗅觉测试中对青少年进行评估，在该测试中，他们有机会研究具有酒精气味或香草气味的洞（这里使用的大鼠品系自然偏好的气味剂）。只有青少年与酒精中毒的同龄人进行了互动，发现表现出显着的变化，酒精气味的偏好相比，适当的控制，与非醉酒的同龄人进行互动。单独的酒精气味暴露或与麻醉酒精中毒的同伴的相互作用不足以建立对酒精感官线索偏好的变化。结果表明，社会互动与醉酒的同龄人决定高度偏好酒精线索在青少年。这种偏好的建立似乎需要醉酒的行为表现，而不仅仅是依赖于嗅觉预先暴露于酒精的线索。(C)2004年爱思唯尔公司All rights reserved.
This study focuses on "passive social influences" (alcohol-related information acquired by an organism that interacts with an intoxicated counterpart) that can potentially affect alcohol preference in adolescent rats. Five experiments were conducted to investigate whether repeated social interactions with an intoxicated peer can generate alcohol-related memories that lead an animal to exhibit heightened alcohol olfactory preference patterns. Juvenile experiences with alcohol were operationalized as follows: interactions with an alcohol-intoxicated peer (Experiment 1), with an alcohol-scented cotton surrogate (Experiment 2) or with an anesthetized alcohol-intoxicated partner (Experiments 35). Periadolescents were then evaluated in a two-way location olfactory test where they had the opportunity to investigate a hole scented with alcohol odor or vanilla (an odorant naturally preferred by the strain of rats here utilized). Only juveniles that interacted with an alcohol-intoxicated peer were found to exhibit a significant change in alcohol odor preferences when compared to appropriate controls that interacted with a non-intoxicated peer. Alcohol odor exposure alone or interactions with an anesthetized alcohol-intoxicated peer were not sufficient to establish changes in preference for alcohol sensory cues. Results indicate that social interactions with an intoxicated peer determine heightened preference for alcohol cues in periadolescents. The establishment of this preference seems to require behavioral manifestations of the intoxicated counterpart, instead of just being dependent on an olfactory pre-exposure to alcohol cues. (C) 2004 Elsevier Inc. All rights reserved.