LTR retrotransposon-gene associations in Drosophila melanogaster
LTR retrotransposon-gene associations in Drosophila melanogaster
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DOI：
10.1007/s00239-004-0312-4
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发表时间：
2006-01-01
影响因子：
3.9
通讯作者：
McDonald, JF
中科院分区：
文献类型：
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作者：
Ganko, EW;Greene, CS;McDonald, JF
在已测序的果蝇基因组中，发现33%（228/682）的长末端重复序列（LTR）反转录转座子序列（LRS）位于基因的1000 bp内。最近插入的LTR反转录转座子更有可能位于基因中或基因内比旧的，片段化的LTR反转录转座子序列，表明大多数LRS基因协会选择反对在进化时间。与保守基因（同源基因）相关的LRS特别容易受到负选择。与此相反，在进化过程中长期存在于基因组中的片段化LRS优先与参与信号转导和其他新进化功能的基因相关。
Thirty-three percent (228/682) of all long terminal repeat (LTR) retrotransposon sequences (LRSs) present in the sequenced Drosophila melanogaster genome were found to be located in or within 1000 bp of a gene. Recently inserted LTR retrotransposons are significantly more likely to be located in or within genes than are older, fragmented LTR retrotransposon sequences, indicating that most LRS-gene associations are selected against over evolutionary time. LRSs associated with conserved genes (homologenes) are especially prone to negative selection. In contrast, fragmented LRSs that have persisted in the genome over long spans of evolutionary time are preferentially associated with genes involved in signal transduction and other newly evolved functions.