Acid inhibition of sham feeding-stimulated gastrin release and gastric acid secretion: effect of atropine.
Acid inhibition of sham feeding-stimulated gastrin release and gastric acid secretion: effect of atropine.
复制标题
假喂养刺激的胃泌素释放和胃酸分泌的酸抑制：阿托品的作用。
DOI：
10.1016/0016-5085(80)90682-4
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发表时间：
1980
期刊：
影响因子：
29.4
通讯作者：
J. Walsh
中科院分区：
文献类型：
--
作者：
M. Feldman;J. Walsh
在健康受试者中研究了假喂养时，胃内pH值对胃泌素反应的影响。在假喂养之前、期间和之后，将酸化的生理盐水溶液（pH值为5.0或2.5）连续注入胃中，并通过体内灌胃滴定将胃内pH值维持在5.0或2.5。当胃内pH维持在5.0时，假喂养引起的迷走神经刺激释放的胃泌素量具有统计学意义。酸化至pH 2.5消除了胃泌素反应，并抑制了假喂养时约50%的酸分泌反应。小剂量阿托品（2.3 μg/kg）可阻止pH为2.5时胃泌素释放的抑制。此外，在阿托品存在的情况下，酸化至pH 2.5不会抑制假喂养刺激的酸分泌。这些发现表明，假性喂养刺激的胃泌素释放和胃酸分泌的酸抑制是通过阿托品敏感途径介导的。
The effect of intraluminal pH on the gastrin response to sham feeding was studied in healthy subjects. Before, during, and after sham feeding, an acidified solution of saline (at either pH 5.0 or 2.5) was infused into the stomach continuously and intragastric pH was maintained at either 5.0 or 2.5 by in vivo intragastric titration. When intragastric pH was maintained at 5.0, vagal stimulation induced by sham feeding released statistically significant amounts of gastrin. Acidification to pH 2.5 abolished the gastrin response and also inhibited by approximately 50% the acid secretory response to sham feeding. A small dose of atropine (2.3 μg/kg) prevented the inhibition of gastrin release which had occurred at pH 2.5. Moreover, in the presence of atropine, acidification to pH 2.5 did not inhibit acid secretion stimulated by sham feeding. These findings suggest that acid inhibition of sham feeding-stimulated gastrin release and gastric acid secretion is mediated by an atropine-sensitive pathway.