Expression and Clinical Significance of Androgen Receptor in Triple-Negative Breast Cancer.
Expression and Clinical Significance of Androgen Receptor in Triple-Negative Breast Cancer.
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DOI：
10.3390/cancers9010004
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发表时间：
2017-01-06
期刊：
影响因子：
5.2
通讯作者：
Ohira M
中科院分区：
文献类型：
--
作者：
Asano Y;Kashiwagi S;Goto W;Tanaka S;Morisaki T;Takashima T;Noda S;Onoda N;Ohsawa M;Hirakawa K;Ohira M
背景：三阴性乳腺癌（TNBC）因复发频繁而预后不良。雄激素受体（AR）参与了乳腺癌的发病机制，但其作用尚不明确。本研究旨在探讨AR在TNBC中的表达及其与临床病理特征的关系。方法：对1036例散发性浸润性乳腺癌患者的临床资料进行分析。进行免疫组织化学测定以确定190个TNBC样品中AR的表达。分析AR表达与临床病理资料及预后的关系。结果如下：在190例TNBC病例中，AR阳性患者的预后显著优于AR阴性患者（p = 0.019，对数秩），在多变量分析中，AR表达是预后良好的独立指标（p = 0.039，风险比= 0.36）。在疾病复发的患者中，AR阳性与较好的预后显著相关（p = 0.034，对数秩）。结论：AR表达可能是TNBC预后的一个亚分类指标。
Background: Triple-negative breast cancer (TNBC) has a poor prognosis because of frequent recurrence. Androgen receptor (AR) is involved in the pathogenesis of breast cancer, but its role is not clearly defined. The aim of this study was to explore the expression of AR and its relationship with clinicopathologic features in TNBC. Methods: This study investigated 1036 cases of sporadic invasive breast carcinoma. Immunohistochemical assays were performed to determine the expression of AR in 190 TNBC samples. The relationships between AR expression and clinicopathologic data and prognosis were analyzed. Results: In 190 TNBC cases, the prognosis of AR-positive patients was significantly better (p = 0.019, log-rank) than AR-negative patients, and in multivariate analysis, AR expression was an independent indicator of good prognosis (p = 0.039, hazard ratio = 0.36). In patients with disease relapse, AR positivity was significantly correlated with better prognosis (p = 0.034, log-rank). Conclusions: AR expression may be useful as a subclassification marker for prognosis in TNBC.