Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment
Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment
复制标题
DOI：
10.1182/blood-2006-01-0017
复制
发表时间：
2006-07-01
期刊：
影响因子：
20.3
通讯作者：
Lucas, Bruno
中科院分区：
文献类型：
--
作者：
Martin, Bruno;Becourt, Chantal;Lucas, Bruno
自我识别在维持外周血CD4(+) t细胞池中的作用已被广泛研究，但迄今为止还没有明确的答案。事实上，在研究自身主要组织相容性复合体（MHC）分子在CD4(+) T细胞存活中的作用时，在解释结果时必须考虑几个参数：(1)在淋巴细胞减少的环境中，MHC表达小鼠中T细胞的伴随增殖导致观察结果有偏差；(2)外周t细胞区室在非淋巴细胞减少、正常和MHC ii类缺陷小鼠中在质量和数量上存在差异；(3)在C57BL/6 A(β)（-/-）小鼠（传统上认为MHC II类缺陷）中，A（α）链和E- β链结合形成A(α)E(β) MHC II类杂交分子。鉴于这些考虑，我们重新审视了与MHC II类分子的相互作用在外周血CD4(+) T细胞存活中的作用。我们发现，对于“CD4(+) T细胞存活是否需要自我识别？”这个问题的答案并不是简单的是或否。事实上，尽管CD4(+) T细胞的长期存活并不依赖于淋巴细胞减少小鼠的自我识别，但在非淋巴细胞减少的环境中，维持外周血CD4(+) T细胞池需要与MHC II类分子的相互作用。
The role of self-recognition in the maintenance of the peripheral CD4(+) T-cell pool has been extensively studied, but no clear answer has so far emerged. Indeed, in studies of the role of self-major histocompatibility complex (MHC) molecules in CD4(+) T-cell survival, several parameters must be taken into account when interpreting the results: (1) in a lymphopenic environment, observations are biased by concomitant proliferation of T cells arising in MHC-expressing mice; (2) the peripheral T-cell compartment is qualitatively and quantitatively different in nonlymphopenic, normal, and MHC class II-deficient mice; and (3) in C57BL/6 A(beta)(-/-) mice (traditionally considered MHC class II-deficient), the A(alpha) chain and the E-beta chain associate to form a hybrid A(alpha)E(beta) MHC class II molecule. In light of these considerations, we revisited the role of interactions with MHC class II molecules in the survival of peripheral CD4(+) T cells. We found that the answer to the question "is self-recognition required for CD4(+) T cells to survive?" is not a simple yes or no. Indeed, although long-term survival of CD4(+) T cells does not depend on self-recognition in lymphopenic mice, interactions with MHC class II molecules are required for maintaining the peripheral CD4(+) T-cell pool in a nonlymphopenic environment.