Pulling the trigger: Noncoding RNAs in white adipose tissue browning
Pulling the trigger: Noncoding RNAs in white adipose tissue browning
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DOI：
10.1007/s11154-023-09866-6
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Guoping Li
中科院分区：
文献类型：
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作者：
Dehuan Liang;Guoping Li
White adipose tissue (WAT) serves as the primary site for energy storage and endocrine regulation in mammals, while .brown adipose tissue (BAT) is specialized for thermogenesis and energy expenditure. The conversion of white adipocytes .to brown-like fat cells, known as browning, has emerged as a promising therapeutic strategy for reversing obesity and its .associated co-morbidities. Noncoding RNAs (ncRNAs) are a class of transcripts that do not encode proteins but exert .regulatory functions on gene expression at various levels. Recent studies have shed light on the involvement of ncRNAs in .adipose tissue development, diferentiation, and function. In this review, we aim to summarize the current understanding .of ncRNAs in adipose biology, with a focus on their role and intricate mechanisms in WAT browning. Also, we discuss the .potential applications and challenges of ncRNA-based therapies for overweight and its metabolic disorders, so as to combat .the obesity epidemic in the future.
