Perinatal Exposure to Traffic-Related Air Pollution and Autism Spectrum Disorders.
Perinatal Exposure to Traffic-Related Air Pollution and Autism Spectrum Disorders.
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DOI：
10.1289/ehp118
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发表时间：
2017-01
影响因子：
10.4
通讯作者：
Pershagen G
中科院分区：
文献类型：
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作者：
Gong T;Dalman C;Wicks S;Dal H;Magnusson C;Lundholm C;Almqvist C;Pershagen G
来自美国的研究表明，早年暴露在空气污染中与儿童患有自闭症谱系障碍(ASD)有关，但证据与欧洲的数据不一致。我们的目标是调查暴露在道路交通中的空气污染与儿童患自闭症风险之间的联系，并仔细调整社会经济和其他混杂因素。1993-2007年期间在瑞典斯德哥尔摩出生和居住的儿童被诊断为自闭症，通过多个健康登记册进行了确认，并将其归类为病例(n=5,136)。从同一研究基地随机选择的18237名儿童组成了对照组。用弥散模型估算了居民点母亲孕期和婴儿出生一年期间道路交通排放的氮氧化物(NOx)和可吸入颗粒物(≤10μm)水平。用Logistic回归模型估计有或无智力残疾(ID)的ASD的优势比(OR)和95%可信区间(CI)，并对潜在的混杂因素进行调整。围产期空气污染暴露与自闭症总体无相关性(OR=1.00；95%CI：0.86，1.15/10μg/m~3；OR=1.02；95%CI：0.94，1.10/20μg/m~3孕期NOx增加)。在生命的第一年暴露于空气中，以及在患有自闭症的情况下，也观察到了类似的结果。在怀孕期间搬到新住所的母亲的孩子中，观察到空气污染暴露与自闭症风险之间的负相关。早期接触道路交通中低水平的NOx和PM10似乎不会增加ASD的风险。龚涛，达尔曼C，威克斯，S，达尔H，马格努森C，伦德霍尔姆C，阿尔姆奎斯特C，佩尔沙根G。2017。围产期暴露于与交通相关的空气污染和自闭症谱系障碍。环境健康展望125119126；http://dx.doi.org/10.1289/EHP118
Studies from the United States indicate that exposure to air pollution in early life is associated with autism spectrum disorders (ASD) in children, but the evidence is not consistent with European data. We aimed to investigate the association between exposure to air pollution from road traffic and the risk of ASD in children, with careful adjustment for socioeconomic and other confounders. Children born and residing in Stockholm, Sweden, during 1993–2007 with an ASD diagnosis were identified through multiple health registers and classified as cases (n = 5,136). A randomly selected sample of 18,237 children from the same study base constituted controls. Levels of nitrogen oxides (NOx) and particulate matter with diameter ≤ 10 μm (PM10) from road traffic were estimated at residential addresses during mother’s pregnancy and the child’s first year of life by dispersion models. Odds ratios (OR) and 95% confidence intervals (CI) for ASD with or without intellectual disability (ID) were estimated using logistic regression models after conditioning on municipality and calendar year of birth as well as adjustment for potential confounders. Air pollution exposure during the prenatal period was not associated with ASD overall (OR = 1.00; 95% CI: 0.86, 1.15 per 10-μg/m3 increase in PM10 and OR = 1.02; 95% CI: 0.94, 1.10 per 20-μg/m3 increase in NOx during mother’s pregnancy). Similar results were seen for exposure during the first year of life, and for ASD in combination with ID. An inverse association between air pollution exposure and ASD risk was observed among children of mothers who moved to a new residence during pregnancy. Early-life exposure to low levels of NOx and PM10 from road traffic does not appear to increase the risk of ASD. Gong T, Dalman C, Wicks S, Dal H, Magnusson C, Lundholm C, Almqvist C, Pershagen G. 2017. Perinatal exposure to traffic-related air pollution and autism spectrum disorders. Environ Health Perspect 125:119–126; http://dx.doi.org/10.1289/EHP118