Geographic variation of the predictive values of genomic mutations associated with streptomycin resistance in Mycobacterium tuberculosis
Geographic variation of the predictive values of genomic mutations associated with streptomycin resistance in Mycobacterium tuberculosis
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DOI：
10.1006/mcpr.1996.0086
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发表时间：
1997-04-01
影响因子：
3.3
通讯作者：
Rinder, H
中科院分区：
文献类型：
--
作者：
Dobner, P;Bretzel, G;Rinder, H
结核分枝杆菌中与链霉素(SM)耐药相关的特定突变表明其具有快速预测能力。然而，与任何诊断试验一样，它们的预测价值取决于它们的流行程度。本文对来自德国的25株SM抗性分离株和来自塞拉利昂的25株SM抗性分离株的rars和rpsL基因突变进行了分析和比较。RRS基因突变在两个地区的分离株中都很少见(分别为20%和12%)，因此预测价值有限。相比之下，在48%的德国分离株中发现了rpsL突变，但在塞拉利昂分离株中只有24%发现了rpsL突变。结论是，该基因突变的预测值可能会因研究样本的来源而显著不同。(C)1997年学术出版社有限公司。
Specific mutations associated with resistance to streptomycin (SM) in Mycobacterium tuberculosis suggest themselves for its rapid prediction. However, as with any diagnostic test, their predictive values are dependent on their prevalences. In this report, SM resistance associated mutations in the rrs and rpsL genes of 25 SM resistant isolates from Germany and 25 SM resistant isolates from Sierra Leone were characterized and compared. Mutations in the rrs gene were infrequent in isolates from both localities (20% and 12%, respectively) and thus of limited predictive values. In contrast, rpsL mutations were found in 48% of the German isolates but only in 24% of the isolates from Sierra Leone. It is concluded that the predictive values of mutations in this gene may vary significantly with the origin of the samples under investigation. (C) 1997 Academic Press Limited.