GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders.
GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders.
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DOI：
10.1016/j.neuropharm.2009.07.027
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发表时间：
2009-10
影响因子：
4.7
通讯作者：
Brandon, Nicholas J.
中科院分区：
文献类型：
--
作者：
Charych, Erik I.;Liu, Feng;Moss, Stephen J.;Brandon, Nicholas J.
关键词：
γ-氨基丁酸 A 型 (GABAA) 受体在介导大脑中快速突触抑制方面发挥着重要作用。它们在中枢神经系统中普遍表达，也是临床相关药物的主要作用位点。最近的技术进步极大地阐明了不同的 GABAA 受体亚基类别和亚型在正常大脑功能中所发挥的分子和细胞作用。与此同时，尸检和遗传学研究已将包括精神分裂症和双相情感障碍在内的神经精神疾病与 GABA 能神经传递和各种特定的 GABAA 受体亚基联系起来，而表明 GABAAR 相关蛋白的证据也开始出现。在这篇综述中，我们讨论了越来越多的遗传、分子和细胞证据，这些证据表明 GABAA 受体异质性在精神分裂症病因学和治疗开发中的作用。最后，我们推测精神分裂症相关疾病与选定的 GABAA 受体相关蛋白之间的关系，这些蛋白是 GABAA 受体运输、靶向、聚集和锚定的关键调节因子，通常以亚型特异性的方式执行这些功能。
γ-amino butyric acid type A (GABAA) receptors play an important role in mediating fast synaptic inhibition in the brain. They are ubiquitously expressed in the CNS and also represent a major site of action for clinically relevant drugs. Recent technological advances have greatly clarified the molecular and cellular roles played by distinct GABAA receptor subunit classes and isoforms in normal brain function. At the same time, postmortem and genetic studies have linked neuropsychiatric disorders including schizophrenia and bipolar disorder with GABAergic neurotransmission and various specific GABAA receptor subunits, while evidence implicating GABAAR-associated proteins is beginning to emerge. In this review we discuss the mounting genetic, molecular, and cellular evidence pointing toward a role for GABAA receptor heterogeneity in both schizophrenia etiology and therapeutic development. Finally, we speculate on the relationship between schizophrenia-related disorders and selected GABAA receptor associated proteins, key regulators of GABAA receptor trafficking, targeting, clustering, and anchoring that often carry out these functions in a subtype-specific manner.
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影响因子：
4.8
作者：
Brandon, NJ;Delmas, P;Moss, SJ
通讯作者：
Moss, SJ
DOI：
10.1073/pnas.96.17.9891
发表时间：
1999-08-17
影响因子：
11.1
作者：
Bonnert, TP;McKernan, RM;Whiting, PJ
通讯作者：
Whiting, PJ
DOI：
10.1073/pnas.241503698
发表时间：
2001-11-20
影响因子：
11.1
作者：
Akwa, Y;Ladurelle, N;Baulieu, EE
通讯作者：
Baulieu, EE
影响因子：
3.7
作者：
Alessi, Amy;Bragg, April D.;Adams, Marvin E.
通讯作者：
Adams, Marvin E.
影响因子：
30.8
作者：
Allen, Nicole C.;Bagade, Sachin;Bertram, Lars
通讯作者：
Bertram, Lars