The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response.
The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response.
复制标题
DOI：
10.1038/tp.2016.187
复制
发表时间：
2016-11-01
影响因子：
6.8
通讯作者：
Weinshilboum R
中科院分区：
文献类型：
--
作者：
Biernacka JM;Sangkuhl K;Jenkins G;Whaley RM;Barman P;Batzler A;Altman RB;Arolt V;Brockmöller J;Chen CH;Domschke K;Hall-Flavin DK;Hong CJ;Illi A;Ji Y;Kampman O;Kinoshita T;Leinonen E;Liou YJ;Mushiroda T;Nonen S;Skime MK;Wang L;Baune BT;Kato M;Liu YL;Praphanphoj V;Stingl JC;Tsai SJ;Kubo M;Klein TE;Weinshilboum R
发表后，作者发现 ISPC、AMPS 和 STAR* D 数据的荟萃分析存在错误。该错误是由于在对三项研究的结果进行荟萃分析之前未能正确协调某些 SNP 上的等位基因而造成的。该错误对主要分析没有影响，主要分析仅关注 ISPC 数据（表 2、图 1），但导致表 3 中列出了几个不正确的信号（荟萃分析结果）。更正后的表 3 以及更正后的图 2（曼哈顿荟萃分析图）如下所示。新的补充文件可在线获取。对文章的更正如下所述。在摘要中，句子“响应荟萃分析中的顶级关联结果包括 HPRTP4（次黄嘌呤磷酸核糖基转移酶假基因 4）/VSTM5（V 集和跨膜结构域包含 5）区域中的单核苷酸多态性（SNP），该区域接近全基因组显着性（P = 5.03 E−08）和 SNP 5'上游神经调节蛋白-1 基因，NRG1 (P= 1.20 E− 06)”应为“响应荟萃分析中的顶部关联结果代表神经调节蛋白-1 基因，NRG1 (P= 1.20 E− 06) 上游 5' 的 SNP。”
Following publication, the authors identified an error in the meta-analysis of ISPC, AMPS and STAR* D data. The error resulted from a failure to correctly harmonize alleles at some SNPs prior to meta-analyzing results from the three studies. This error had no impact on the primary analysis, which focused on the ISPC data alone (Table 2, Figure 1), but resulted in several incorrect signals being listed in Table 3 (meta-analysis results). The corrected Table 3 is shown below, along with a corrected Figure 2 (Manhattan plot of the meta-analysis). A new Supplementary File is available online. The corrections to the article are described below.In the Abstract, the sentence ‘Top association results in the metaanalysis of response included single-nucleotide polymorphisms (SNPs) in the HPRTP4 (hypoxanthine phosphoribosyltransferase pseudogene 4)/VSTM5 (V-set and transmembrane domain containing 5) region, which approached genome-wide significance (P= 5.03 E− 08) and SNPs 5′ upstream of the neuregulin-1 gene, NRG1 (P= 1.20 E− 06)’should read ‘The top association result in the meta-analysis of response represents SNPs 5′ upstream of the neuregulin-1 gene, NRG1 (P= 1.20 E− 06).’