Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19
Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19
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DOI：
10.1016/j.jaut.2020.102463
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发表时间：
2020-08-01
影响因子：
12.8
通讯作者：
Chang, Christopher
中科院分区：
文献类型：
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作者：
Li, Guoping;He, Xiang;Chang, Christopher
据报道，SARS-CoV-2可能以ACE 2作为受体进入人体细胞，其方式与SARS-CoV相似。因此，分析ACE 2的分布和表达水平可能有助于揭示病毒易感性和感染后调节的潜在机制。在这项研究中，我们利用先前上传的包括SARS-CoA在内的各种条件下ACE 2表达的信息来评估ACE 2在SARS-CoV中的作用，并将其外推到COVID-19。我们发现ACE 2在健康人群和有基础疾病的患者中的表达没有显著差异。然而，基于吸烟者中ACE 2的表达升高，我们推测长期吸烟可能是COVID-19的一个危险因素。对SARS-CoV感染细胞中ACE 2的分析表明，ACE 2不仅是一种受体，而且还参与感染后的调节，包括免疫应答、细胞因子分泌和病毒基因组复制。此外，我们构建了蛋白质-蛋白质相互作用（PPI）网络，并确定了病毒活性和细胞因子分泌的枢纽基因。我们的发现可能有助于临床医生和研究人员更深入地了解SARS-CoV-2的发病机制，并设计COVID-19的治疗策略。
It has been reported that SARS-CoV-2 may use ACE2 as a receptor to gain entry into human cells, in a way similar to that of SARS-CoV. Analyzing the distribution and expression level of ACE2 may therefore help reveal underlying mechanisms of viral susceptibility and post-infection modulation. In this study, we utilized previously uploaded information on ACE2 expression in various conditions including SARS-CoA to evaluate the role of ACE2 in SARS-CoV and extrapolate that to COVID-19. We found that the expression of ACE2 in healthy populations and patients with underlying diseases was not significantly different. However, based on the elevated expression of ACE2 in cigarette smokers, we speculate that long-term smoking may be a risk factor for COVID-19. Analysis of ACE2 in SARS-CoV infected cells suggests that ACE2 is not only a receptor but is also involved in post-infection regulation, including immune response, cytokine secretion, and viral genome replication. Moreover, we constructed Protein-protein interaction (PPI) networks and identified hub genes in viral activity and cytokine secretion. Our findings may help clinicians and researchers gain more insight into the pathogenesis of SARS-CoV-2 and design therapeutic strategies for COVID-19.