Rho GTPases and actomyosin: Partners in regulating epithelial cell-cell junction structure and function.
Rho GTPases and actomyosin: Partners in regulating epithelial cell-cell junction structure and function.
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DOI：
10.1016/j.yexcr.2017.03.053
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发表时间：
2017-09-01
影响因子：
3.7
通讯作者：
Miller AL
中科院分区：
文献类型：
--
作者：
Arnold TR;Stephenson RE;Miller AL
Epithelial tissues are defined by polarized epithelial cells that are integrated into tissues and exhibit barrier function in order to regulate what is allowed to pass between cells. Cell-cell junctions must be stable enough to promote barrier function and tissue integrity, yet plastic enough to remodel when necessary. This remarkable ability to dynamically sense and respond to changes in cell shape and tissue tension allows cell-cell junctions to remain functional during events that disrupt epithelial homeostasis including morphogenesis, wound healing, and cell division. In order to achieve this plasticity, both tight junctions and adherens junctions are coupled to the underlying actomyosin cytoskeleton. Here, we discuss the importance of the junctional linkage to actomyosin and how a localized zone of active RhoA along with other Rho GTPases work together to orchestrate junctional actomyosin dynamics. We focus on how scaffold proteins help coordinate Rho GTPases, their upstream regulators, and their downstream effectors for efficient, localized Rho GTPase signaling output. Additionally, we highlight important roles junctional actin-binding proteins play in addition to their traditional roles in organizing actin. Together, Rho GTPases, their regulators, and effectors form compartmentalized signaling modules that regulate actomyosin structure and contractility to achieve proper cell-cell adhesion and tissue barriers.
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影响因子：
3.3
作者：
Braga, VMM;Betson, M;Lamarche-Vane, N
通讯作者：
Lamarche-Vane, N
影响因子：
3.3
作者：
Breznau EB;Semack AC;Higashi T;Miller AL
通讯作者：
Miller AL
α-肌动蛋白在肠上皮细胞连接络合物中的定位。
DOI：
10.1083/jcb.80.1.203
发表时间：
1979-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Craig SW;Pardo JV
通讯作者：
Pardo JV
影响因子：
9.2
作者：
Ebrahim, Seham;Fujita, Tomoki;Millis, Bryan A.;Kozin, Elliott;Ma, Xuefei;Kawamoto, Sachiyo;Baird, Michelle A.;Davidson, Michael;Yonemura, Shigenobu;Hisa, Yasuo;Conti, Mary Anne;Adelstein, Robert S.;Sakaguchi, Hirofumi;Kachar, Bechara
通讯作者：
Kachar, Bechara
cingulin包含球形和盘绕螺旋域，并与ZO-1，ZO-2，ZO-3和肌球蛋白相互作用。
影响因子：
7.8
作者：
Cordenonsi, M;D'Atri, F;Hammar, E;Parry, D A;Kendrick-Jones, J;Shore, D;Citi, S
通讯作者：
Citi, S