Aggressive conservative therapy for refractory ulcer with diabetes and/or arteriosclerosis
Aggressive conservative therapy for refractory ulcer with diabetes and/or arteriosclerosis
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积极保守治疗合并糖尿病和/或动脉硬化的难治性溃疡
DOI：
10.1111/j.1346-8138.2006.00082.x
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
M. Ishii
中科院分区：
文献类型：
--
作者：
H. Motomura;Natsuko Ohashi;T. Harada;M. Muraoka;M. Ishii
由于糖尿病和/或动脉硬化闭塞症（阿索）引起的足部溃疡经常导致难以治疗的顽固性病症。为了科普这种情况下，我们已经开发了一种联合治疗，包括传统的保守治疗加手术治疗。采用积极清创、曲弗明（Fiblast Spray，卡肯，日本）治疗和真空辅助闭合（VAC）治疗的积极保守疗法治疗7例糖尿病和阿索相关难治性足部溃疡伴骨暴露患者。除1例患者在治疗过程中死亡外，其余6例患者均获得保肢。平均治愈时间8.3个月。在截肢前应考虑这种方法。有些患者可能拒绝截肢或不能耐受高侵入性手术治疗，包括组织移植。在这种情况下，这种积极的保守治疗可以作为一个非常有用的和可重复的技术，需要简单的技术。
A foot ulcer due to diabetes and/or arteriosclerosis obliterans (ASO) frequently results in an intractable condition that resists treatment. To cope with this condition, we have developed a combination therapy that includes conventional conservative therapy plus surgical therapy. This aggressive conservative therapy using aggressive debridement, trafermin (Fiblast Spray, Kaken, Japan) treatment and vacuum‐assisted closure (VAC) therapy was adopted to treat seven patients suffering from diabetes and ASO‐related refractory foot ulcer accompanied by bone exposure. With the exception of one patient who died during the treatment, the remaining six patients obtained limb salvage. The mean time to cure was 8.3 months. This approach should be considered before amputation. Some patients may refuse amputation or cannot tolerate highly invasive surgical treatment including tissue transplantation. In such cases, this aggressive conservative therapy can be employed as a highly useful and reproducible technique requiring simple techniques.
使用生长因子产品治疗骨外露的深部伤口的积极体验。
DOI：
--
发表时间：
2005
期刊：
Journal of Wound Care 14
影响因子：
--
作者：
Ichioka S;et al.
通讯作者：
et al.