The Relationship of Cytokines IL-13 and IL-17 with Autoantibodies Profile in Early Rheumatoid Arthritis.
The Relationship of Cytokines IL-13 and IL-17 with Autoantibodies Profile in Early Rheumatoid Arthritis.
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DOI：
10.1155/2016/3109135
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发表时间：
2016
影响因子：
4.1
通讯作者：
Siloşi CA
中科院分区：
文献类型：
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作者：
Siloşi I;Boldeanu MV;Cojocaru M;Biciuşcă V;Pădureanu V;Bogdan M;Badea RG;Avramescu C;Petrescu IO;Petrescu F;Siloşi CA
目标。在本研究中，我们的目的是评估早期类风湿性关节炎（eRA）患者血清中IL-13和IL-17的浓度，研究这些细胞因子浓度与疾病活动评分之间的相关性，以及一些自身抗体的浓度，并评估IL-13和-17浓度测量作为疾病活动标志物的实用性。材料和方法。从30名患者和28名对照中收集血清样品并分析参数。结果与对照组相比，eRA患者的IL-13、IL-17、抗CCP和IgM-RF的血清浓度在统计学上显著升高。重度和中度eRA组IL-13浓度显著高于轻度和对照组。此外，在IL-17的情况下，血清浓度与eRA的疾病活动成比例增加。我们观察到IL-13和IL-17的浓度与自身抗体无关。IL-17浓度与CRP呈显著正相关，IL-13浓度与CRP呈显著负相关。疾病活动性评分DAS 28与ESR水平呈强正相关，与抗RA 33自身抗体浓度呈弱正相关。IL-13作为疾病活动性的标志物具有比IL-17、CRP、ESR、IgM-RF和抗CCP更高的诊断效用。结论.与对照组相比，患者血清中存在较高的IL-13和IL-17水平，证实了这些具有高度特异性的标志物可能参与eRA的发病机制。IL-13和IL-17在预测eRA活动状态方面可能优于IgM-RF和抗CCP。
Aims. In the present study, we aimed to assess the concentrations of IL-13 and IL-17 in serum of patients with early rheumatoid arthritis (eRA), the investigation of correlation between the concentrations of these cytokines and disease activity score, and the concentration of some autoantibodies and the evaluation of the utility of IL-13 and -17 concentration measurements as markers of disease activity. Materials and Methods. Serum samples were collected from 30 patients and from 28 controls and analysed parameters. Results. The serum concentrations of IL-13, IL-17, anti-CCP, and IgM-RF were statistically significantly higher in patients with eRA, compared to the controls. IL-13 concentrations in the severe and moderate groups with eRA were statistically higher than in the mild and control groups. Also, in the case of IL-17, serum concentrations increased proportionally with the disease activity of eRA. We observe that concentrations of IL-13 and -17 did not correlate with autoantibodies. IL-17 concentration significantly positively correlated with CRP, while IL-13 concentration significantly negatively correlated with CRP. Disease activity score, DAS28, was strongly positively correlated with levels of ESR and weakly positively correlated with concentrations of anti-RA33 autoantibodies. IL-13 has a higher diagnostic utility than IL-17, CRP, ESR, IgM-RF, and anti-CCP as markers of disease activity. Conclusions. The presence of higher IL-13 and IL-17 serum levels in patients, compared with those of controls, confirms that these markers, found with high specificity, might be involved in the pathogenesis of eRA. IL-13 and IL-17 might be of better usefulness in the prediction of eRA activity status than IgM-RF and anti-CCP.