Human encephalitis caused by pseudorabies virus infection: a case report
Human encephalitis caused by pseudorabies virus infection: a case report
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DOI：
10.1007/s13365-019-00822-2
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发表时间：
2020-01-02
影响因子：
3.2
通讯作者：
Wang, Jinquan
中科院分区：
文献类型：
--
作者：
Wang, Di;Tao, Xiaogen;Wang, Jinquan
伪狂犬病病毒（PRV）主要感染猪，但也可感染牛、狗和猫。几项研究报道了PRV可以跨越物种屏障并诱导人类脑炎，但由于缺乏PRV DNA检测，人类PRV脑炎的明确诊断是有争议的。在这里，我们报告了一例人类PRV脑炎诊断的下一代测序（NGS）的PRV序列在脑脊液（CSF）的病人。一名男性猪肉小贩出现发烧和癫痫发作6天。NGS结果显示他的脑脊液和血液中有PRV序列。桑格测序结果显示脑脊液中PRV DNA阳性，脑脊液和血液中PRV抗体阳性。MRI结果显示双侧半球多发性炎性病变。根据临床和实验室检查资料，我们诊断为PRV脑炎。该病例表明PRV可感染人类，引起严重的病毒性脑炎。存在PRV感染风险的人群应提高自我保护意识。
Pseudorabies virus (PRV) primarily infects swine but can infect cattle, dogs, and cats. Several studies have reported that PRV can cross the specie barrier and induce human encephalitis, but a definitive diagnosis of human PRV encephalitis is debatable due to the lack of PRV DNA detection. Here, we report a case of human PRV encephalitis diagnosed by the next-generation sequencing (NGS) of PRV sequences in the cerebrospinal fluid (CSF) of a patient. A male pork vendor developed fever and seizures for 6 days. NGS results showed PRV sequences in his CSF and blood. Sanger sequencing showed that PRV DNA in the CSF and PRV antibodies in both the CSF and blood were positive. MRI results revealed multiple inflammatory lesions in the bilateral hemisphere. Based on the clinical and laboratory data, we diagnosed the patient with PRV encephalitis. This case suggests that PRV can infect humans, causing severe viral encephalitis. People at risk of PRV infection should improve their self-protection awareness.