An integrated database of the ascidian, Ciona intestinalis:: Towards functional genomics
An integrated database of the ascidian, Ciona intestinalis:: Towards functional genomics
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DOI：
10.2108/zsj.22.837
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发表时间：
2005-08-01
影响因子：
0.9
通讯作者：
Satoh, Nori
中科院分区：
文献类型：
--
作者：
Satou, Yutaka;Kawashima, Takeshi;Satoh, Nori
一个完整的基因组数据库是未来功能基因组学研究的基础。本研究更新了海鞘Ciona spiritus的cDNA和基因组资源，并通过扩展已发表的数据库，提供了一个完整的基因组和cDNA数据库。更新后的资源包括超过190，000个EST（加上以前的EST共672，396个）和超过1，000个全插入序列（共6，773个）。此外，将确定的支架信息映射到染色体上的结果、来自全长富集cDNA文库的用于指示基因的精确5 '末端的EST、以及不同个体之间的SNP和indel的比较都整合到该数据库中，所有这些结果最近都被报道。这些进展继续增加玻璃海鞘作为模式生物的效用，而综合数据库将有助于研究人员在比较和进化基因组学。
An integrated genome database is essential for future studies of functional genomics. In this study, we update cDNA and genomic resources of the ascidian, Ciona intestinalis, and provide an integrated database of the genomic and cDNA data by extending a database published previously. The updated resources include over 190,000 ESTs (672,396 in total together with the previous ESTs) and over 1,000 full-insert sequences (6,773 in total). In addition, results of mapping information of the determined scaffolds onto chromosomes, ESTs from a full-length enriched cDNA library for indication of precise 5'-ends of genes, and comparisons of SNPs and indels among different individuals are integrated into this database, all of these results being reported recently. These advances continue to increase the utility of Ciona intestinalis as a model organism whilst the integrated database will be useful for researchers in comparative and evolutionary genomics.