The quality of reporting of trial abstracts is suboptimal: Survey of major general medical journals
The quality of reporting of trial abstracts is suboptimal: Survey of major general medical journals
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DOI：
10.1016/j.jclinepi.2008.05.013
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发表时间：
2009-04-01
影响因子：
7.2
通讯作者：
Cook, Deborah
中科院分区：
文献类型：
--
作者：
Berwanger, Otavio;Ribeiro, Rodrigo A.;Cook, Deborah
目的：评估四个主要普通医学期刊上发表的描述随机对照试验（RCT）摘要的报告质量。 研究设计和设置：对已发表的 RCT 摘要进行系统调查，由两名评审员独立提取数据。我们检索了 MEDLINE，找到了 2006 年发表在《新英格兰医学杂志》(NEJM)、《美国医学会杂志》(JAMA)、《英国医学杂志》(BMJ) 和《轮胎柳叶刀》上的 227 篇 RCT 摘要。结果：大多数摘要将研究确定为随机试验 (98.7%)，报告了目标 (92.5%)，描述了人群 (90.3%)，详细介绍了干预措施（81.5%），并定义了主要结局（71.3%）。方法学质量报告不佳：1 例 (0.4%) 描述了分配隐藏； 21 (9.3%) 明确指定盲法； 51 (22.5%) 描述了意向治疗分析； 32 名 (14.1%) 概述了后续的损失。大多数摘要报告了效应大小和置信区间（62.3%），但只有一半报告了副作用或危害。结论：主要普通医学期刊上发表的随机对照试验摘要的报告质量不理想。尽管存在空间限制，但根据摘要联盟最近的建议，预计摘要报告的透明度可以而且应该得到提高。 (C) 2009 Elsevier Inc. 保留所有权利。
Objective: To evaluate the quality of reporting of abstracts describing randomized controlled trials (RCTs) published in four major general medical journals.Study Design and Setting: Systematic survey of published RCT abstracts, with two reviewers independently extracting data. We searched MEDLINE and identified 227 RCT abstracts published in the New England Journal of Medicine (NEJM), Journal of the American Medical Association (JAMA), British Medical Journal (BMJ), and Tire Lancet in the year 2006.Results: Most abstracts identified the study as a randomized trial (98.7%), reported the objectives (92.5%), described the population (90.3%), detailed the intervention (81.5%), and defined the primary outcome (71.3%). Methodological quality was poorly reported: one (0.4%) described allocation concealment; 21 (9.3%) clearly specified blinding; 51 (22.5%) described intention-to-treat analysis; and 32 (14.1%) outlined losses to follow-up. Most of the abstracts reported the effect size and the confidence intervals (62.3%), but just half of them reported side effects or harms.Conclusion: The quality of reporting of RCT abstracts published in main general medical journals is suboptimal. Space limitations notwithstanding, with the recent recommendations from the CONSORT for Abstracts, it is expected that the transparency of abstract reporting can and should improve. (C) 2009 Elsevier Inc. All rights reserved.