Meisetz, a novel histone tri-methyltransferase, regulates meiosis-specific epigenesis
Meisetz, a novel histone tri-methyltransferase, regulates meiosis-specific epigenesis
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DOI：
10.4161/cc.5.6.2572
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发表时间：
2006-03-16
期刊：
影响因子：
4.3
通讯作者：
Matsui, Yasuhisa
中科院分区：
文献类型：
--
作者：
Hayashi, Katsuhiko;Matsui, Yasuhisa
减数分裂是一种特殊的细胞分裂，对于减少基因组的倍性和产生所有有性生殖生物的基因组多样性至关重要。我们最近的研究发现，减数分裂特异性组蛋白甲基转移酶Meisetz（Meiosis-induced factor containing PR/SET domain and zinc finger motif）在小鼠生殖细胞系减数分裂前期的正常进行中起着重要作用。这一发现还表明，生殖细胞谱系具有与体细胞谱系不同的减数分裂特异性表观遗传状态。本文综述了Meisetz的功能，并展望了小鼠生殖细胞减数分裂正常进行的表观遗传学背景。
Meiosis is a specialized cell division that is essential to reduce the ploidy of the genome and to generate genomic diversity in all sexually reproducing organisms. Our recent investigation revealed that the meiosis-specific histone methyltransferase Meisetz (Meiosis-induced factor containing PR/SET domain and zinc-finger motif) played an essential role on proper progression of meiotic prophase in mouse germ cell lineage. The finding also suggests that the germ cell lineage has a meiosis-specific epigenetic status that is different from that of the somatic cell lineage. This article reviews the function of Meisetz and prospects the epigenetic background allowing proper progression of meiosis in mouse germ cells.