Estrogen receptor a gene polymorphism in schizophrenia: frequency, age at onset, symptomatology and prognosis
Estrogen receptor a gene polymorphism in schizophrenia: frequency, age at onset, symptomatology and prognosis
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DOI：
10.1097/00041444-200106000-00007
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发表时间：
2001-06-01
影响因子：
0.9
通讯作者：
Tsai, SJ
中科院分区：
文献类型：
--
作者：
Ouyang, WC;Wang, YC;Tsai, SJ
精神分裂症在两性中分布均匀；然而，女性发病较晚，精神病理较轻，预后较好。这种性别差异被认为部分是由雌激素系统造成的。最近的研究已经确定雌激素受体α亚型（ER α）遗传多态性可能影响ER α的表达，并与阿尔茨海默病有关。在这项研究中，我们调查了125名精神分裂症患者和142名对照者的ER α多态性的关联。在基因型分布和等位基因频率方面，对照组与精神分裂症患者无显著差异。ER α基因型与发病年龄、精神症状或精神分裂症患者的预后无关。随着新的研究强调性激素在神经和心理功能障碍中的突出作用，需要进一步研究性激素受体基因在易感性精神障碍中的遗传作用及其与不同表型的关联。《精神病学杂志》第11卷第1期。
Schizophrenic disorders are equally distributed for both sexes; however, later onset, milder psychopathology and better outcome are associated with the female gender. This sex difference is thought to be partly due to the estrogen system. Recent studies have determined that estrogen receptor alpha subtype (ER alpha) genetic polymorphisms may affect the expression of ER alpha, and are associated with Alzheimer's disease. For this study, we investigated the association of ER alpha polymorphisms for 125 schizophrenic patients and 142 control subjects. No significant differences for genotype distribution or allele frequency were revealed comparing controls and schizophrenic patients. The ER alpha genotypes were not associated with onset age, psychiatric symptoms or outcome for schizophrenic cases. With new research highlighting the prominent role of sex hormones in neurological and psychological dysfunction, further study is needed to explore the genetic effect of the sex hormone receptor gene on susceptibility mental disorders and associations with different phenotypes. Psychiatr Genet 11:95-98 (C) 2001 Lippincott Williams & Wilkins.