Cohort profile: seek, test, treat and retain United States criminal justice cohort.
Cohort profile: seek, test, treat and retain United States criminal justice cohort.
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DOI：
10.1186/s13011-017-0107-4
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发表时间：
2017-05-16
期刊：
影响因子：
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通讯作者：
Crane HM
中科院分区：
文献类型：
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作者：
Chandler R;Gordon MS;Kruszka B;Strand LN;Altice FL;Beckwith CG;Biggs ML;Cunningham W;Chris Delaney JA;Flynn PM;Golin CE;Knight K;Kral AH;Kuo I;Lorvick J;Nance RM;Ouellet LJ;Rich JD;Sacks S;Seal D;Spaulding A;Springer SA;Taxman F;Wohl D;Young JD;Young R;Crane HM
STTR治疗级联提供了一个研究框架，旨在改善公共卫生机构的服务、护理和结果。开发有效的方法来增加艾滋病毒诊断，并在治疗级联的后续步骤中加入PLWH，可能导致更早和持续的抗逆转录病毒治疗，从而抑制病毒。应用治疗级联来改善那些涉及刑事司法的人的结果的研究需求尚未得到满足。寻求、检测、治疗和保留（STTR）刑事司法（CJ）队列结合了来自艾滋病毒治疗级联的11项研究的数据，这些研究的重点是涉及刑事司法系统的人员，通常但不完全是由于与药物使用有关的原因。这些研究在不同的CJ环境中进行，并收集了11个预先选择的领域的信息：人口统计学特征、CJ参与、艾滋病毒风险行为、艾滋病毒和/或丙型肝炎感染、CD4 t细胞计数（CD4）和艾滋病毒RNA病毒载量（VL）的实验室测量、精神疾病、健康相关生活质量（QoL）、社会经济地位、卫生保健获取、物质使用和社会支持。STTR CJ队列包括11,070名感染或未感染艾滋病毒的患者的数据，年龄从18岁到77岁，基线年龄中位数为37岁。该队列反映了美国CJ系统中的种族、民族和性别分布，64%的参与者是非裔美国人，12%是西班牙裔，83%是男性。队列成员报告了广泛的艾滋病毒风险行为，包括注射吸毒史，在报告监禁前性行为的人中，无保护性交的流行率在研究中从4%到79%不等。在所有研究中，53%的STTR CJ队列报告了近期的多物质使用。STTR CJ队列由来自各种CJ环境的参与者组成，包括监狱，监狱和社区监督，他们在特征和行为实践方面报告了相当大的差异。在可行的情况下，我们制定了统一的措施，以改进这些研究的综合，以回答否则无法解决的问题。
The STTR treatment cascade provides a framework for research aimed at improving the delivery of services, care and outcomes of PLWH. The development of effective approaches to increase HIV diagnoses and engage PLWH in subsequent steps of the treatment cascade could lead to earlier and sustained ART treatment resulting in viral suppression. There is an unmet need for research applying the treatment cascade to improve outcomes for those with criminal justice involvement. The Seek, Test, Treat, and Retain (STTR) criminal justice (CJ) cohort combines data from 11 studies across the HIV treatment cascade that focused on persons involved in the criminal justice system, often but not exclusively for reasons related to substance use. The studies were conducted in a variety of CJ settings and collected information across 11 pre-selected domains: demographic characteristics, CJ involvement, HIV risk behaviors, HIV and/or Hepatitis C infections, laboratory measures of CD4 T-cell count (CD4) and HIV RNA viral load (VL), mental illness, health related quality of life (QoL), socioeconomic status, health care access, substance use, and social support. The STTR CJ cohort includes data on 11,070 individuals with and without HIV infection who range in age from 18 to 77 years, with a median age at baseline of 37 years. The cohort reflects racial, ethnic and gender distributions in the U.S. CJ system, and 64% of participants are African-American, 12% are Hispanic and 83% are men. Cohort members reported a wide range of HIV risk behaviors including history of injection drug use and, among those who reported on pre-incarceration sexual behaviors, the prevalence of unprotected sexual intercourse ranged across studies from 4% to 79%. Across all studies, 53% percent of the STTR CJ cohort reported recent polysubstance use. The STTR CJ cohort is comprised of participants from a wide range of CJ settings including jail, prison, and community supervision who report considerable diversity in their characteristics and behavioral practices. We have developed harmonized measures, where feasible, to improve the integration of these studies together to answer questions that cannot otherwise be addressed.