Clinical treatment of ocular demodecosis by lid scrub with tea tree oil
Clinical treatment of ocular demodecosis by lid scrub with tea tree oil
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DOI：
10.1097/01.ico.0000244870.62384.79
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发表时间：
2007-02-01
期刊：
影响因子：
2.8
通讯作者：
Tseng, Scheffer C. G.
中科院分区：
文献类型：
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作者：
Gao, Ying-Ying;Di Pascuale, Mario A.;Tseng, Scheffer C. G.
目的：目的：探讨茶树油眼睑擦洗治疗眼部蠕形螨病的临床疗效。方法：回顾性分析11例眼部蠕形螨病患者的临床疗效。这11名患者还患有睑板腺功能障碍（n = 7），表现为脂质膜异常，脂质膜扩散缓慢，间歇性倒睫（n = 5），和主观睫毛损失（n = 4），表明对睑板腺和睫毛毛囊的损害。此外，结膜炎症（n = 8）与结膜炎（n = 5）、结膜松弛症（n = 3）、疑似类天疱疮（n = 2）和复发性翼状胬肉（n = 2）相关。TTO眼睑擦洗后，11例患者中有8例在不到4周的时间内连续2次访视的蠕形螨计数降至0。11例患者中有10例表现出不同程度的症状缓解和炎症体征明显减轻。22只眼中有6只眼的视力显著改善与脂质扩散时间显著减少引起的稳定脂质泪膜相关。结论：蠕形螨可能导致眼表炎症，睑板腺功能障碍，睫毛异常。用TTO擦洗眼睑可有效清除眼部蠕形螨，并导致主观和客观改善。这一初步的阳性结果保证了未来对蠕形螨致病性的前瞻性研究。
Purpose: To report clinical outcome of treating ocular demodecosis by lid scrub with tea tree oil (TTO).Methods: Retrospective review of clinical results in 11 patients with ocular Demodex who received weekly lid scrub with 50% TTO combined with daily lid hygiene with tea tree shampoo.Results: These 11 patients also had meibomian gland dysfunction (n = 7) manifesting abnormal lipid film with slow lipid film spread, intermittent trichiasis (n = 5), and subjective lash loss (n = 4), suggesting damage to the meibomian glands and lash follicles. In addition, conjunctival inflammation (n = 8) was associated with conjunctivitis (n = 5), conjunctivochalasis (n = 3), findings suspicious for pemphigoid (n = 2), and recurrent pterygium (n = 2). After TTO lid scrub, the Demodex count dropped to 0 for 2 consecutive visits in less than 4 weeks in 8 of 11 patients. Ten of the 11 patients showed different degrees of symptomatic relief and notable reduction of inflammatory signs. Significant visual improvement in 6 of 22 eyes was associated with a stable lipid tear film caused by significant reduction of lipid spread time. Lid scrub with 50% TTO caused notable irritation in 3 patients.Conclusion: Demodex potentially causes ocular surface inflammation, meibomian gland dysfunction, and lash abnormalities. Lid scrub with TTO can effectively eradicate ocular Demodex and result in subjective and objective improvements. This preliminary positive result warrants future prospective investigation of Demodex pathogenicity.