Danger and loss events and the incidence of anxiety and depressive disorders: a prospective-longitudinal community study of adolescents and young adults

Danger and loss events and the incidence of anxiety and depressive disorders: a prospective-longitudinal community study of adolescents and young adults
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DOI:
10.1017/s0033291714001160
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发表时间:
2015-01-01
影响因子:
6.9
通讯作者:
Beesdo-Baum, K.
Beesdo-Baum, K.
中科院分区:
医学1区
文献类型:
--
作者:
Asselmann, E.;Wittchen, H. -U.;Beesdo-Baum, K.

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背景。关于危险和损失事件是否能不同地预测焦虑和抑郁的发生,目前尚无定论。一个社区青少年和年轻人样本(n=2304,基线年龄14-24岁)在10年内进行了多达4次的前瞻性随访。使用DSM-IV/M-CIDI评估每一波的突发焦虑和抑郁障碍。使用慕尼黑事件列表(MEL)在基线上评估生活事件(包括危险、损失和各自的混合事件)。使用逻辑回归来揭示基线时的事件类型与随访时的事件障碍之间的关联。丧失事件仅能预测“纯粹”抑郁事件[比值比(OR) 2.4 /标准差,95%置信区间(CI) 1.5-3.9, p
Background. There are inconclusive findings regarding whether danger and loss events differentially predict the onset of anxiety and depression.Method. A community sample of adolescents and young adults (n=2304, age 14-24 years at baseline) was prospectively followed up in up to four assessments over 10 years. Incident anxiety and depressive disorders were assessed at each wave using the DSM-IV/M-CIDI. Life events (including danger, loss and respectively mixed events) were assessed at baseline using the Munich Event List (MEL). Logistic regressions were used to reveal associations between event types at baseline and incident disorders at follow-up.Results. Loss events merely predicted incident 'pure' depression [odds ratio (OR) 2.4 per standard deviation, 95% confidence interval (CI) 1.5-3.9, p