The role of neurotensin in physiologic and pathologic processes
The role of neurotensin in physiologic and pathologic processes
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DOI：
10.1097/med.0b013e3283419052
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发表时间：
2011-02-01
影响因子：
3.2
通讯作者：
Evers, B. Mark
中科院分区：
文献类型：
--
作者：
Mustain, W. Conan;Rychahou, Piotr G.;Evers, B. Mark
研究目的神经降压素是一种由13个氨基酸组成的多肽，存在于中枢神经系统、中枢神经系统和胃肠道。自1973年首次发现以来，神经降压素已被证明在人体内广泛的生理和病理过程中发挥作用。正在进行的研究工作继续澄清神经降压素在各种中枢神经系统和胃肠道过程中的作用，以及这些正常机制的破坏可能如何导致从精神分裂症到结直肠癌等疾病。本综述的目的是根据先前发表的文献综述神经降压素研究领域的最新进展。最近的发现由于神经降压素在中枢神经系统和外周的功能看似无关，所以综述的文章范围相当广泛。我们对神经降压素信号的下游效应以及神经降压素和其他信号分子之间的复杂反馈回路的理解继续做出贡献。通过选择性地靶向或阻断特定的神经降压素受体，研究人员已经确定了用于治疗精神分裂症、酒精中毒、慢性疼痛或癌症的潜在药物。以神经降压素为基础的药理药物已成功地在动物模型中用于治疗许多此类疾病。综述重点介绍了神经降压素在多种生物学过程中的作用，并总结了神经降压素各个领域的最新研究进展。通过这项研究获得的知识导致了用于治疗各种疾病的一流药物的开发，很明显，在未来几年，这些药物中的一些将准备好在临床试验中从替补席上转移到床边。
Purpose of reviewNeurotensin is a 13-amino acid peptide found in the central nervous system central nervous system and the gastrointestinal tract. Since its initial discovery in 1973, neurotensin has been shown to play a role in a wide range of physiologic and pathologic processes throughout the body. Ongoing research efforts continue to clarify the role of neurotensin in various central nervous system and gastrointestinal processes, as well as how disruption of these normal mechanisms may lead to diseases ranging from schizophrenia to colorectal cancer. The goal of this review is to provide an overview of the most recent advances in the field of neurotensin research, in the context of what has been previously published.Recent findingsBecause of the seemingly unrelated functions of neurotensin in the central nervous system and the periphery, the scope of the articles reviewed is rather broad. Contributions continue to be made to our understanding of the downstream effects of neurotensin signaling and the complex feedback loops between neurotensin and other signaling molecules. By selective targeting or blockade of specific neurotensin receptors, investigators have identified potential drugs for use in the treatment of schizophrenia, alcoholism, chronic pain, or cancer. Neurotensin-based pharmacologic agents are being used successfully in animal models for a number of these conditions.SummaryThe review highlights the wide array of biological processes in which neurotensin has a role, and summarizes the most recent advances in various fields of neurotensin research. The knowledge gained through this research has led to the development of first-in-class drugs for the treatment of various medical conditions, and it is clear that in the coming years some of these agents will be ready to move from the bench to the bedside in clinical trials.