Positive and negative schizotypy in a student sample: neurocognitive and clinical correlates
Positive and negative schizotypy in a student sample: neurocognitive and clinical correlates
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DOI：
10.1016/s0920-9964(01)00230-4
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发表时间：
2002-07-01
影响因子：
4.5
通讯作者：
Andover, MS
中科院分区：
文献类型：
--
作者：
Dinn, WM;Harris, CL;Andover, MS
阳性和阴性分裂型可能代表离散的因素或维度。为了确定不同的神经认知特征是否与这些维度或因素相关，我们根据阳性和阴性分裂型症状对大学生进行了分类，并进行了单独的分析。在神经精神病学文献的基础上，我们预测，在非临床学生样本中，微妙的前额叶缺陷将选择性地与消极分裂型人格特征相关联。我们还研究了积极/消极分裂型与相关临床状态或人格维度（包括反社会人格障碍、强迫症人格特征、广义和社交焦虑、共情和冲动）之间的关系。将受试者分为阳性和阴性分裂型组显示出不同的神经认知和临床特征。我们观察到颞叶功能障碍、冲动、反社会行为和积极的精神分裂现象之间的正相关。负性精神分裂与额叶执行功能测量的细微表现缺陷、社交焦虑增加和强迫症现象有关。研究结果与阳性和阴性分裂型代表离散因素的论点一致。(C) 2002 Elsevier Science B.V.版权所有
Positive and negative schizotypy may represent discrete factors or dimensions. To determine if distinct neurocognitive profiles are associated with these dimensions or factors, we classified university students on the basis of positive and negative schizotypal symptoms and conducted separate analyses. Following prior work in the neuropsychiatric literature, we predicted that subtle prefrontal deficits would be selectively associated with negative schizotypal personality features in a nonclinical student sample, We also investigated the relationship between positive/negative schizotypy and associated clinical states or personality dimensions including antisocial personality disorder, obsessive-compulsive personality traits, generalized and social anxiety, empathy, and impulsivity. Classification of subjects into positive and negative schizotypy groups revealed distinct neurocognitive and clinical profiles. We observed a positive relation between measures of temporolimbic dysfunction, impulsivity, antisocial behavior, and positive schizotypal phenomena. Negative schizotypy was associated with subtle performance deficits on measures of frontal executive function, increased social anxiety, and obsessive-compulsive phenomena. Findings are consistent with the contention that positive and negative schizotypy represent discrete factors. (C) 2002 Elsevier Science B.V. All rights reserved.