Environmental Exposures, the Epigenome, and African American Women's Health.
Environmental Exposures, the Epigenome, and African American Women's Health.
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环境暴露、表观基因组和非裔美国妇女的健康。
DOI：
10.1007/s11524-018-00332-2
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Ohm,JoyceE
中科院分区：
文献类型：
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作者：
Ohm,JoyceE
压力是现代生活的一个共同特征，但压力暴露的程度和这些压力暴露的下游影响在个人、社区和人群之间可能会有很大差异。当个人暴露在反复或长期的压力下时，身体上的磨损会以多种方式积累和表现出来。“恒定负荷”一词代表反复或长期暴露在环境应激源下的生理后果，与波动和/或神经或神经内分泌反应增强有关。非洲裔美国妇女是一个被确定为潜在地具有较高的稳态负荷和对外部因素的韧性增强的人口亚群。环境应激源可能影响人类健康的一个机制是通过基因组的表观遗传重塑。这篇综述将集中在关于不同类型的环境应激源如何影响表观基因组的已知情况，并探索表观遗传重新编程与改变的稳态负荷和弹性之间的联系，因为它与非裔美国女性的健康有关。
Stress is a common feature of modern life, but both the extent of exposure to stressors and the downstream effects of these stress exposures can vary considerably among individuals, communities, and populations. When individuals are exposed to repeated or chronic stress, wear and tear on the body can accumulate and manifest in many ways. The term “allostatic load” represents the physiological consequences of repeated or chronic exposure to environmental stressors and is linked to fluctuating and/or heightened neural or neuroendocrine responses. African American women are one population subgroup that has been identified as potentially having both an elevated allostatic load and an enhanced resilience to external factors. One mechanism by which environmental stressors may impact human health is via epigenetic remodeling of the genome. This review will focus on what is known about how different types of environmental stressors may affect the epigenome and explore links between epigenetic reprogramming and altered allostatic load and resilience as it pertains to African American women’s health.