The Influence of Deleterious Mutations on Adaptation in Asexual Populations
The Influence of Deleterious Mutations on Adaptation in Asexual Populations
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DOI：
10.1371/journal.pone.0027757
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发表时间：
2011-11-14
期刊：
影响因子：
3.7
通讯作者：
Tao, Shiheng
中科院分区：
文献类型：
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作者：
Jiang, Xiaoqian;Xu, Zhao;Tao, Shiheng
我们研究的动态适应无性种群经历有益和有害的突变。特别地，研究了有害突变如何影响有益突变的固定。通过大量的MonteCarlo模拟，我们发现在“强选择弱突变（SSWM）”或“克隆干扰（CI）”机制中，有害突变很少影响“固定突变选择系数（SCFM）”的分布;而在“多突变”机制中，有害突变的积累会导致适应度显著下降.我们的结论是，有害突变对适应的影响在很大程度上取决于有益突变的供应。有趣的是，最低的适应率发生在中等值的有害突变的选择系数。
We study the dynamics of adaptation in asexual populations that undergo both beneficial and deleterious mutations. In particular, how the deleterious mutations affect the fixation of beneficial mutations was investigated. Using extensive Monte Carlo simulations, we find that in the "strong-selection weak mutation (SSWM)'' regime or in the "clonal interference (CI)'' regime, deleterious mutations rarely influence the distribution of "selection coefficients of the fixed mutations (SCFM)''; while in the "multiple mutations'' regime, the accumulation of deleterious mutations would lead to a decrease in fitness significantly. We conclude that the effects of deleterious mutations on adaptation depend largely on the supply of beneficial mutations. And interestingly, the lowest adaptation rate occurs for a moderate value of selection coefficient of deleterious mutations.