Kami-shoyo-san, Kampo (Japanese traditional medicine), is effective for climacteric syndrome, especially in hormone-replacement-therapy-resistant patients who strongly complain of psychological symptoms
Kami-shoyo-san, Kampo (Japanese traditional medicine), is effective for climacteric syndrome, especially in hormone-replacement-therapy-resistant patients who strongly complain of psychological symptoms
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DOI：
10.1111/j.1447-0756.2012.01936.x
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发表时间：
2013-01-01
影响因子：
1.6
通讯作者：
Saito, Shigeru
中科院分区：
文献类型：
--
作者：
Hidaka, Takao;Yonezawa, Rika;Saito, Shigeru
目的：针对更年期症状的激素替代疗法（HRT）对潮热、出汗等血管舒缩症状有效，但对焦虑、抑郁、烦躁等各种心理症状无效。在这种情况下，有时会考虑使用汉方（传统草药）。然而，汉方的有效性尚未明确显示。我们检查了 Kami-shoyo-san 的临床效果，Kami-shoyo-san 是日本汉方诊所常用的治疗更年期症状的草药配方。方法：有180名患者因HRT无反应或改善不理想而首次到我们汉方门诊就诊。在 180 名患者中，45 名患者根据以患者为中心的汉方诊断，接受了为期 4 周的 Kami-shoyo-san 提取物。我们根据 Kami-shoyo-san 给药前后 4 周的视觉模拟量表 (VAS) 评分评估更年期症状的严重程度。此外，还比较了有反应者和无反应者在治疗前每种症状的严重程度。结果：Kami-shoyo-san 对 45 名患者中的 33 名（73.3%）有效。治疗后总体来看VAS评分显着下降（P<0.0001）。关于血管舒缩症状和心理症状，各项VAS评分均显着下降（P<0.0001）。当比较有反应者和无反应者治疗前症状的严重程度时，有反应者的失眠、抑郁和眩晕等症状明显更明显（P < 0.05）。结论：本研究结果表明，Kami-shoyo-san 可以缓解血管舒缩症状和心理症状，特别是对于有明显心理症状的患者，它表现出有效的效果。
Aim: Hormone replacement therapy (HRT) for climacteric symptoms is effective for vasomotor symptoms, such as hot flushes and sweating, but not for various psychological symptoms, such as anxiety, depression, and irritability. In such cases, prescribing Kampo, traditional herbal medicine, is sometimes considered. However, the effectiveness of Kampo has not been clearly shown. We examined the clinical effect of Kami-shoyo-san, a herbal formula commonly prescribed for climacteric symptoms in a Japanese Kampo clinic. Methods: There were 180 patients who initially consulted our Kampo Outpatient Clinic due to the absence of a response to HRT or unsatisfactory improvement. Out of 180 patients, 45 patients received a Kami-shoyo-san extract for 4 weeks based on patient-centered Kampo diagnosis. We evaluated the severity of climacteric symptoms based on the visual analogue scale (VAS) score before and after 4 weeks of Kami-shoyo-san administration. Furthermore, the severity of each symptom before treatment was compared between the responders and non-responders. Results: Kami-shoyo-san was effective in 33 (73.3%) of the 45 patients. After treatment, on the whole, the VAS score significantly decreased (P < 0.0001). Concerning vasomotor symptoms and psychological symptoms, each VAS score significantly decreased (P < 0.0001). When comparing the severity of pretreatment symptoms between responders and non-responders, symptoms, such as insomnia, depression, and vertigo were significantly more marked in the responders (P < 0.05). Conclusion: The results of this study suggest that Kami-shoyo-san relieved both vasomotor and psychological symptoms, and especially in patients with marked psychological symptoms, it exhibited potent effects.