Elevation of soluble form of receptor for advanced glycation end products (sRAGE) in diabetic subjects with coronary artery disease
Elevation of soluble form of receptor for advanced glycation end products (sRAGE) in diabetic subjects with coronary artery disease
复制标题
DOI：
10.1002/dmrr.690
复制
发表时间：
2007-07-01
影响因子：
8
通讯作者：
Imaizumi, Tsutomu
中科院分区：
文献类型：
--
作者：
Nakamura, Kazuo;Yamagishi, Sho-ichi;Imaizumi, Tsutomu
背景糖基化终产物（AGEs）-受体（AGEs-receptor，RECEPTOR）轴参与糖尿病血管并发症的发生.由于可溶性形式的β-淀粉样蛋白（sBMPs）可由内皮细胞（EC）中细胞表面β-淀粉样蛋白的裂解产生，因此糖尿病患者的血清sBMPs水平可能因EC损伤而升高。在这项研究中，我们研究是否sliptin水平升高2型糖尿病患者与非糖尿病healthsubjects.Methods血清sliptin水平进行了检查，在75日本2型糖尿病患者（29名男性和46名女性，平均年龄66 - 11岁）和75年龄和性别匹配的非糖尿病健康对照组。结果糖尿病患者血清胰岛素水平显著高于非糖尿病患者（965.3 ± 544.2pg/mL vs 415 ± 150.4pg/mL，p < 0.001）。在单变量分析中，舒张压（负相关）、LDL胆固醇、甘油三酯、HDL胆固醇、血红蛋白A（1c）和肌酐与血糖显著相关。在进行多变量分析后，糖尿病的存在（p < 0.0001）是糖尿病的唯一独立决定因素。此外，糖尿病合并冠心病患者与无冠心病患者之间的血清肌酐水平存在显著差异（1680.6 +/- 891.1 vs 855.2 +/- 372.1 pg/mL，p < 0.001）。多元逐步回归分析显示，血清肌酐和肌酐水平是冠心病的独立危险因素。结论2型糖尿病患者血清肌酐水平明显高于非糖尿病患者，与冠心病的发生呈正相关。版权所有（c）2006约翰威利父子有限公司。
Background Advanced glycation end products (AGEs)-receptor (RAGE) axis is implicated in diabetic vascular complication. Since a soluble form of RAGE (sRAGE) could be generated from the cleavage of cell surface RAGE in endothelial cells (ECs), serum sRAGE levels may be elevated in diabetes consequent to EC damage. In this study, we examined whether sRAGE levels were elevated in type 2 diabetic patients compared with non-diabetic healthy subjects.Methods Serum sRAGE levels were examined in 75 Japanese type 2 diabetic patients (29 men and 46 women; mean age 66 11 years) and 75 age-and sex-matched non-diabetic healthy control subjects. We explored the association between sRAGE levels and coronary artery disease (CAD) in diabetic patients.Results Serum sRAGE levels were significantly higher in diabetic patients than in non-diabetic subjects (965.3 +/- 544.2 vs 415 +/- 150.4 pg/mL, p < 0.001). In the univariate analysis, diastolic blood pressure (inversely), LDL cholesterol, triglycerides, HDL cholesterol, hemoglobin A(1c), and creatinine were significantly associated with sRAGE. After performing multivariate analyses, the presence of diabetes (p < 0.0001) was a sole independent determinant of sRAGE. Furthermore, there was a significant difference in sRAGE levels between diabetic patients with CAD and those without CAD (1680.6 +/- 891.1 vs 855.2 +/- 372.1 pg/mL, p < 0.001). Multiple stepwise regression analysis revealed that sRAGE and creatinine levels were independent determinants of CAD.Conclusions The present study demonstrated that serum sRAGE levels were significantly higher in type 2 diabetic patients than in non-diabetic subjects and positively associated with the presence of CAD. Copyright (c) 2006 John Wiley & Sons, Ltd.