Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease.
Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease.
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DOI：
10.1016/j.semcdb.2015.03.010
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发表时间：
2015-04
影响因子：
7.3
通讯作者：
Bezprozvanny, Ilya
中科院分区：
文献类型：
--
作者：
Egorova, Polina;Popugaeva, Elena;Bezprozvanny, Ilya
关键词：
Neurodegenerative disorders, such as spinocerebellar ataxias (SCAs) and Alzheimer’s disease (AD) represent a huge scientific and medical question, but the molecular mechanisms of these diseases are still not clear. There is increasing evidence that neuronal calcium signaling is abnormal in many neurodegenerative disorders. Abnormal neuronal calcium release from the endoplasmic reticulum may result in disturbances of cell homeostasis, synaptic dysfunction, and eventual cell death. Neuronal loss is observed in most cases of neurodegenerative diseases. Recent experimental evidence supporting the role of neuronal calcium signaling in the pathogenesis of SCAs and AD is discussed in this review.
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