The action of a water-soluble carbodiimide on adenosine-5'-polyphosphates.
The action of a water-soluble carbodiimide on adenosine-5'-polyphosphates.
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水溶性碳二亚胺对腺苷-5-聚磷酸的作用。
DOI：
10.1093/nar/15.8.3573
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发表时间：
1987
影响因子：
14.9
通讯作者：
Orgel,LE
中科院分区：
文献类型：
--
作者：
Ng,KE;Orgel,LE
当用水溶性碳二亚胺处理腺苷-5 ′-单磷酸、二磷酸或三磷酸的水溶液时，主要产物是预期的二腺苷-5 ′-5′-多磷酸。这些焦磷酸盐的产率在Mg 2+离子的存在下大大增加。腺苷-5 ′-四磷酸的行为不同。主要产物为腺苷-5 ′-单磷酸。我们认为这种水解是通过环状三偏磷酸盐中间体发生的。
When aqueous solutions of adenosine-5′-aono-, di-, or triphosphates are treated with a water soluble carbodiimide the major product is the expected diadenosine-5′-5′-polyphosphate. The yields of these pyrophosphates are greatly increased in the presence of the Mg2+ion. Adenosine-5′-tetraphosphate behaves differently. The major product is adenosine-5′-monophosphate. We believe that this hydrolysis occurs via a cyclic trimetaphosphate intermediate.