Neural reserve, neuronal density in the locus ceruleus, and cognitive decline
Neural reserve, neuronal density in the locus ceruleus, and cognitive decline
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DOI：
10.1212/wnl.0b013e3182897103
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发表时间：
2013-03-01
期刊：
影响因子：
9.9
通讯作者：
Bennett, David A.
中科院分区：
文献类型：
--
作者：
Wilson, Robert S.;Nag, Sukriti;Bennett, David A.
目的：要测试的假设，脑干胺能神经核的神经元密度较高，有助于neural reserve.Methods：参与者是165个人从拉什记忆和衰老项目，纵向临床病理队列研究。他们完成了平均5.8年的年度评估，其中包括一组19项认知测试，从这些测试中得出了先前建立的全球认知综合指标。死亡后，他们有一个大脑尸检和统一的神经病理检查，提供了估计的胺能神经元的密度在蓝斑，中缝背核，黑质，腹侧被盖区加上总结措施的神经元缠结和路易体从这些核和内侧颞叶和neocortical.Results：神经元密度在每个核近似正态分布。在单独的分析中，除了腹侧被盖区之外，每个核中较高的神经元密度与较慢的认知下降速率相关，但是当一起建模时，只有蓝斑神经元密度与认知下降相关（估计值= 0.003，SE = 0.001，p < 0.001）。即使在控制了大脑其他部位的病理负担后，这些脑干核团中更高密度的缠结和路易体也与更快的认知能力下降相关。蓝斑神经元密度、脑干缠结和脑干路易体与认知能力下降率有独立相关性。此外，在更高水平的蓝斑神经元密度，路易体与认知功能减退的协会被initiated.Conclusion：去甲肾上腺素能神经元的密度在蓝斑可能是神经储备的结构组成部分。神经病学（R）2013;80：1202-1208
Objective: To test the hypothesis that higher neuronal density in brainstem aminergic nuclei contributes to neural reserve.Methods: Participants are 165 individuals from the Rush Memory and Aging Project, a longitudinal clinical-pathologic cohort study. They completed a mean of 5.8 years of annual evaluations that included a battery of 19 cognitive tests from which a previously established composite measure of global cognition was derived. Upon death, they had a brain autopsy and uniform neuropathologic examination that provided estimates of the density of aminergic neurons in the locus ceruleus, dorsal raphe nucleus, substantia nigra, and ventral tegmental area plus summary measures of neuronal neurofibrillary tangles and Lewy bodies from these nuclei and medial temporal lobe and neocortex.Results: Neuronal densities in each nucleus were approximately normally distributed. In separate analyses, higher neuronal density in each nucleus except the ventral tegmental area was associated with slower rate of cognitive decline, but when modeled together only locus ceruleus neuronal density was related to cognitive decline (estimate = 0.003, SE = 0.001, p < 0.001). Higher densities of tangles and Lewy bodies in these brainstem nuclei were associated with faster cognitive decline even after controlling for pathologic burden elsewhere in the brain. Locus ceruleus neuronal density, brainstem tangles, and brainstem Lewy bodies had independent associations with rate of cognitive decline. In addition, at higher levels of locus ceruleus neuronal density, the association of Lewy bodies with cognitive decline was diminished.Conclusion: Density of noradrenergic neurons in the locus ceruleus may be a structural component of neural reserve. Neurology (R) 2013;80:1202-1208