Numerical simulation for heat transfer in prostate cancer cryosurgery.
Numerical simulation for heat transfer in prostate cancer cryosurgery.
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DOI：
10.1115/1.1865193
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发表时间：
2005-04
期刊：
影响因子：
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通讯作者：
Jiayao Zhang;G. Sandison;J. Murthy;Lisa X. Xu
中科院分区：
文献类型：
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作者：
Jiayao Zhang;G. Sandison;J. Murthy;Lisa X. Xu
一个全面的计算框架，以模拟在前列腺癌冷冻手术的冷冻过程中的传热。组织被视为非理想材料，其中相变发生在一定的温度范围内，热物理性质是温度依赖性的，并且包括由于血流和代谢引起的加热。通过结合数学优化过程的温度实验研究，在市售冷冻探针和尿道加温器的表面处确定边界条件。对于模拟，基于真实的前列腺的MRI成像数据设计了合适的计算几何形状。焓公式为基础的数值解进行了规定的手术方案，以模仿临床冷冻过程。这种计算框架允许对冷冻手术进行个人规划并客观评估前列腺冷冻手术的有效性。
A comprehensive computational framework to simulate heat transfer during the freezing process in prostate cancer cryosurgery is presented. Tissues are treated as nonideal materials wherein phase transition occurs over a temperature range, thermophysical properties are temperature dependent and heating due to blood flow and metabolism are included. Boundary conditions were determined at the surfaces of the commercially available cryoprobes and urethral warmer by experimental study of temperature combined with a mathematical optimization process. For simulations, a suitable computational geometry was designed based on MRI imaging data of a real prostate. An enthalpy formulation-based numerical solution was performed for a prescribed surgical protocol to mimic a clinical freezing process. This computational framework allows for the individual planning of cryosurgical procedures and objective assessment of the effectiveness of prostate cryosurgery.