PHANTOM AUDITORY SENSATION IN RATS - AN ANIMAL-MODEL FOR TINNITUS
PHANTOM AUDITORY SENSATION IN RATS - AN ANIMAL-MODEL FOR TINNITUS
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DOI：
10.1037/0735-7044.102.6.811
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发表时间：
1988-12-01
影响因子：
1.9
通讯作者：
SASAKI, CT
中科院分区：
文献类型：
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作者：
JASTREBOFF, PJ;BRENNAN, JF;SASAKI, CT
为了测量水杨酸钠注射引起的耳鸣，84只有色大鼠，分布在14组在5个实验中，在一个条件性抑制范例。在实验1中，所有的组进行了训练与条件刺激（CS）组成的偏移的连续背景噪声。一组在巴甫洛夫训练前开始注射水杨酸盐，第二组在训练后开始注射，对照组每天注射生理盐水。当训练前开始注射时，对灭绝的抵抗是深刻的，但在训练后开始注射时，抵抗力最小，这表明水杨酸诱导的作用获得了不同的条件值。在实验2中，我们模仿水杨酸盐的治疗取代7 kHz的音调，而不是各自的注射，导致相当于水杨酸盐诱导的行为的影响。在第三个实验中，我们包括一个3 kHz的CS，并再次复制水杨酸盐的发现。在实验4中，我们降低了动机水平，水杨酸诱导的效果和抑制训练之间的顺序关系被保留。最后，没有水杨酸盐的影响出现时，使用的视觉方式。这些发现支持动物幻听的证明。
In order to measure tinnitus induced by sodium salicylate injections, 84 pigmented rats, distributed among 14 groups in five experiments, were used in a conditioned suppression paradigm. In Experiment 1, all groups were trained with a conditioned stimulus (CS) consisting of the offset of a continuous background noise. One group began salicylate injections before Pavlovian training, a second group started injections after training, and a control group received daily saline injections. Resistance to extinction was profound when injections started before training, but minimal when initiated after training, which suggests that salicylate-induced effects acquired differential conditioned value. In Experiment 2 we mimicked the salicylate treatments by substituting a 7 kHz tone in place of respective injections, resulting in effects equivalent to salicylate-induced behavior. In a third experiment we included a 3 kHz CS, and again replicated the salicylate findings. In Experiment 4 we decreased the motivational level, and the sequential relation between salicylate-induced effects and suppression training was retained. Finally, no salicylate effects emerged when the visual modality was used. These findings support the demonstration of phantom auditory sensations in animals.