Infrequent events transiently activate human prefrontal and parietal cortex as measured by functional MRI
Infrequent events transiently activate human prefrontal and parietal cortex as measured by functional MRI
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DOI：
10.1152/jn.1997.77.3.1630
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发表时间：
1997-03-01
影响因子：
2.5
通讯作者：
GoldmanRakic, P
中科院分区：
文献类型：
--
作者：
McCarthy, G;Luby, M;GoldmanRakic, P
P300是由不频繁的目标事件引发的事件相关电位，其振幅依赖于前一刺激序列提供的上下文，表明其依赖于工作记忆。我们使用对血氧水平敏感的磁共振成像序列来识别在通常用于诱发P300的任务中呈现的罕见视觉目标刺激所引起的区域变化。靶诱发的双侧额中回、下顶叶和后扣带回近下侧的瞬态事件相关激活在靶发生后1.5 s内开始，在1.5 ~ 6 s间达到峰值。这些区域已经在先前的人类神经成像研究和猴子的单单元记录中被确定。作为调节工作记忆的神经系统的组成部分，这表明该系统可能被唤起P300的相同事件激活。
P300 is an event-related potential elicited by infrequent target events whose amplitude is dependent on the context provided by the immediately preceding sequence of stimuli, suggesting its dependence on working memory. We employed magnetic resonance imaging sequences sensitive to blood oxygenation level to identify regional changes evoked by infrequent visual target stimuli presented in a task typically used to elicit P300. Targets evoked transient event-related activation bilaterally in the middle frontal gyrus, in the inferior parietal lobe, and near the inferior aspect of the posterior cingulate gyrus beginning within 1.5 s of target onset and peaking between 1.5 and 6 s. These regions have been identified in previous neuroimaging studies in humans, and in single-unit recordings in monkeys. as components of a neural system mediating working memory, which suggests that this system may be activated by the same events that evoke P300.