No association between cigarette smoking and incidence of plasma cell myeloma: A meta-analysis of 17 observational studies
No association between cigarette smoking and incidence of plasma cell myeloma: A meta-analysis of 17 observational studies
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DOI：
10.1002/ajh.23220
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发表时间：
2012-07-01
影响因子：
12.8
通讯作者：
Brennan, Keith
中科院分区：
文献类型：
--
作者：
Castillo, Jorge J.;Dhami, Pradeep K.;Brennan, Keith
浆细胞骨髓瘤（PCM）是一种淋巴组织增生性疾病，其特征是骨髓内单克隆浆细胞的恶性生长。尽管已经确定了PCM发展的风险因素，但大多数PCM患者的病因仍不清楚。吸烟已被假定为淋巴恶性肿瘤的潜在危险因素;然而，与PCM的关联尚不确定。我们对观察性研究进行了荟萃分析，以评估吸烟与PCM之间的关系（如果有的话）。截至2011年12月的文献检索提供了4项前瞻性队列研究和13项病例对照研究，评价了这种关联。我们的分类荟萃分析显示，曾经、现在和以前的吸烟者与PCM之间没有关联。当通过研究设计、研究质量和报告的地理区域进行分析时，这种缺乏相关性的情况仍然存在。同样，荟萃回归分析显示，与每天吸烟的数量没有关联。总之，我们的荟萃分析表明，吸烟和PCM发病率增加之间没有关系。未来的研究应关注PCM的其他潜在风险因素。
Plasma cell myeloma (PCM) is a lymphoproliferative disorder characterized by the malignant growth of monoclonal plasma cells within the bone marrow. Although risk factors for the development of PCM have been identified, the etiology on the majority of patients with PCM remains unclear. Cigarette smoking has been postulated as a potential risk factor for lymphoid malignancies; however, the association with PCM is inconclusive. We have carried out a meta-analysis of observational studies to assess the relationship, if any, between cigarette smoking and PCM. A literature search through December 2011 rendered 4 prospective cohort and 13 case-control studies evaluating such association. Our categorical meta-analysis showed that there is no association between ever, current, and former smokers and PCM. This lack of association was maintained when analyzing by study design, study quality, and geographical area of report. Similarly, metaregression analysis showed no association with the number of cigarettes smoked per day. In conclusion, our meta-analysis shows that there is no relationship between cigarette smoking and an increased incidence of PCM. Future studies should focus on other potential risk factors for PCM.